N-甲基吡咯烷酮(NMP)
1-Methyl-2-pyrrolidinone
CAS: 872-50-4;2687-44-7
Molecular Formula: C5H9NO
N-甲基吡咯烷酮(NMP) - Names and Identifiers
N-甲基吡咯烷酮(NMP) - Physico-chemical Properties
| Molecular Formula | C5H9NO |
| Molar Mass | 99.13 |
| Density | 1.028 g/mL at 25 °C (lit.) |
| Melting Point | -24 °C (lit.) |
| Boling Point | 202 °C (lit.)81-82 °C/10 mmHg (lit.) |
| Flash Point | 187°F |
| Water Solubility | >=10 g/100 mL at 20 ºC |
| Solubility | ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v) |
| Vapor Presure | 0.29 mm Hg ( 20 °C) |
| Vapor Density | 3.4 (vs air) |
| Appearance | Liquid |
| Color | ≤20(APHA) |
| Odor | Slight amine odor |
| Maximum wavelength(λmax) | ['283nm(MeOH)(lit.)'] |
| Merck | 14,6117 |
| BRN | 106420 |
| pKa | -0.41±0.20(Predicted) |
| PH | 8.5-10.0 (100g/l, H2O, 20℃) |
| Storage Condition | Store at +5°C to +30°C. |
| Stability | Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases. |
| Sensitive | Hygroscopic |
| Explosive Limit | 1.3-9.5%(V) |
| Refractive Index | n20/D 1.479 |
| Physical and Chemical Properties | Characteristics of colorless transparent oily liquid, slightly amine odor. melting point -24.4 ℃ boiling point 203 ℃ relative density 1.0260 refractive index 1.486 flash point 95 ℃ , ether, Ester, ketone, halogenated hydrocarbon, aromatic hydrocarbon miscible. |
| Use | Widely used in advanced lubricating oil refining, polymer synthesis, insulating materials, pesticides, pigments and cleaning agents |
N-甲基吡咯烷酮(NMP) - Risk and Safety
| Risk Codes | R45 - May cause cancer R65 - Harmful: May cause lung damage if swallowed R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R61 - May cause harm to the unborn child R10 - Flammable R46 - May cause heritable genetic damage |
| Safety Description | S41 - In case of fire and / or explosion do not breathe fumes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 1 |
| RTECS | UY5790000 |
| FLUKA BRAND F CODES | 3-8-10 |
| TSCA | Y |
| HS Code | 2933199090 |
| Toxicity | LD50 orally in Rabbit: 3598 mg/kg LD50 dermal Rabbit 8000 mg/kg |
N-甲基吡咯烷酮(NMP) - Upstream Downstream Industry
| Raw Materials | gamma-butyrolactone Methylamine Methylamine |
N-甲基吡咯烷酮(NMP) - Nature
Open Data Verified Data
colorless transparent oily liquid. It is miscible with water, alcohol, ether, Ester, ketone, halogenated hydrocarbon and aromatic hydrocarbon.
Last Update：2024-01-02 23:10:35
N-甲基吡咯烷酮(NMP) - Quality Standard
Open Data Verified Data
purity 95%; Moisture less than 1.3%; Refractive index greater than 4655.
Last Update：2022-01-01 09:24:30
N-甲基吡咯烷酮(NMP) - Preparation Method
Open Data Verified Data
& gamma;-butyrolactone is reacted with methylamine. After completion of the reaction, the reaction is cooled, Excess methylamine and water are removed, and the product is concentrated, followed by distillation under reduced pressure.
Last Update：2022-01-01 09:24:31
N-甲基吡咯烷酮(NMP) - Use
Open Data Verified Data
excellent advanced solvent, widely used in petrochemical, pesticide, medical, electronic materials and other fields. It can be used for synthesis gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extractant, agricultural herbicide, insulating material, integrated circuit production, pvc tail gas recovery, cleaning agent, Dye auxiliary agent, dispersant, etc.
Last Update：2022-01-01 09:24:32
N-甲基吡咯烷酮(NMP) - Safety
Open Data Verified Data
mouse, rat LD50( mL/kg):3.5, 2.2 (intravenous);4.3, 3. 4 (intraperitoneal injection);7.5, 3. 8 (by mouth). The allowable limit concentration in air is 100 x lO-6. Flammable liquid should be sealed and protected from moisture and light.
Last Update：2022-01-01 09:24:32
N-甲基吡咯烷酮(NMP) - Reference Information
| pH range of acid-base indicator discoloration | 7.7 - 8.0 |
| LogP | -0.46 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | N-methylpyrrolidone (NMP), molecular formula: C5H9NO, English: 1-methyl-2-pyrrollidinone, appearance is colorless to light yellow transparent liquid, slightly ammonia odor, miscible with water in any proportion, soluble in ether, acetone and Ester, halogenated hydrocarbons, aromatic hydrocarbons and other organic solvents, almost completely mixed with all solvents, boiling point 204 ℃, flash point 91 ℃, strong hygroscopicity, stable chemical properties, no corrosion to carbon steel, aluminum, slightly corrosive to copper. It has the advantages of low viscosity, good chemical stability and thermal stability, high polarity, low volatility, infinite miscibility with water and many organic solvents. This product is a micro drug, the allowable limit concentration in the air is 100PPM. |
| reference quality index | inspection item index appearance colorless transparent liquid (above 25 ℃) purity% ≥ 99.5 moisture% ≤ 0.1 chroma HaZen ≤ 25 refractive index N20D 1.468-1.471 density 1.032-1.035 |
| Use | N-methylpyrrolidone (NMP) is a polar aprotic solvent. With low toxicity, high boiling point, superior dissolution. The advantages of strong selectivity and good stability. Widely used in aromatic extraction, acetylene, olefin, Diene purification, polyvinylidene fluoride solvent, lithium ion battery electrode auxiliary material, synthesis gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction agent, insoluble engineering plastics polymerization solvents, agricultural herbicides, insulating materials, integrated circuit manufacturing, semiconductor industry precision instruments, circuit board cleaning, PVC tail gas recovery, cleaning agents, dye additives, dispersants, etc. It is also used as a solvent for polymers and as a medium for polymerization, such as engineering plastics and aramid fibers. In addition, it can also be used in pesticides, pharmaceuticals, detergents and the like. The main uses of different grades of N-methyl pyrrolidone are listed below: 1. Industrial grade: lubricating oil refining, lubricating oil antifreeze, synthesis gas desulfurization, electronic insulation materials, agricultural herbicides, pesticide additives, PVC tail gas recovery, high-grade coatings, inks, pigments and other production additives and dispersants. For example, it can be used as a solvent for extracting aromatic hydrocarbons in lubricating oil to achieve the purpose of refining lubricating oil. Because NMP has great solubility to resin, it can be used as a solvent for resin processing in the manufacture of coatings, floor paints, varnishes, composite coating film, integrated circuit enameled wire insulation materials, fiber fabrics and adhesives and other products. 2. Ordinary Grade: Extraction and recovery of basic organic raw materials, such as acetylene concentration and extraction of butadiene, isoprene and aromatic hydrocarbons. It can be used as a solvent for recovering acetylene from natural gas or light naphtha thermal pyrolysis gas, and the purity of the Concentrated Acetylene can be recovered to 99.7%. As an extractant for separating and recovering high purity butadiene from cracked C4 hydrocarbons, the recovery rate was 97%, and the purity of recovered butadiene was 99.7%. It was used as an extractant for recovering high purity isoprene from C5 hydrocarbons, and the recovery purity of isoprene was 99%; when used as aromatic extractant, because of its high solubility and low vapor pressure for aromatic hydrocarbons, the loss rate of extractant is low and the recovery rate of aromatic hydrocarbons is high. 3, reagent grade: Integrated circuits, hard disks and other requirements to strictly control the metal ions and fine particles of the industry, degreasing, dewaxing, polishing, rust, paint, etc, such as used as Photoresist removal liquid, IC semiconductor industry precision instruments, LCD liquid crystal materials, PCB Printed circuit board, hard disk cleaning; And artificial kidney functional membrane liquid, seawater desalination membrane liquid and other solvents produced in the pharmaceutical industry. is an excellent solvent, which is widely used as an extractant for aromatic extraction, lubricating oil refining, acetylene concentration, synthesis gas desulfurization, etc, N-methyl pyrrolidone is an excellent extraction solvent, widely used for aromatic extraction, acetylene concentration, the extraction agent in the process of butadiene separation and desulfurization of synthesis gas is also a solvent in the production of pesticides, engineering plastics, coatings, synthetic fibers, integrated circuits, etc., and can also be used as industrial detergents, dispersants, dyes, lubricating Oil antifreeze, etc. The product has low toxicity, rats oral LD50 is 7ml/kg. widely used in advanced lubricating oil refining, polymer synthesis, insulating materials, pesticides, pigments and cleaning agents, etc. used in aromatic extraction, purification of acetylene, olefins and diolefins; solvent for polymer and polymerization medium, such as polyamide, polyimide, polyphenylene sulfide and other engineering plastics and aramid fiber used as solvent and extractant. NMP is a polar aprotic solvent with low toxicity, The advantages of high boiling point, superior solubility, strong selectivity and good stability. Widely used in aromatic extraction; Acetylene, olefin, Diene purification. Solvents that are also used for the polymer and media for the polymerization reaction are required. Such as polyamide, polyimide, polyphenylene sulfide and other engineering plastics and aramid fiber. In addition, it is also used for insulating materials, pesticides, pigments and detergents. |
| production method | is derived from the reaction of γ-butyrolactone with methylamine. The first step of the reaction is the formation of 4-hydroxy-n-methylbutyramide from γ-butyrolactone and methylamine, and the second step is further dehydration to N-methylpyrrolidone. The two-step reaction can be carried out continuously in a tubular reactor with a molar ratio of γ-butyrolactone to methylamine of 1:1.15, a pressure of about 6MPA and a temperature of 250 °c. After completion of the reaction, the reaction mixture was concentrated and distilled under reduced pressure to obtain a finished product. The yield was 90%. If the kettle type counter is used for production, the amount of methylamine is 1.5-2.5 times of the theoretical amount, and the laboratory preparation is taken as an example. In a 280 ml autoclave, 2mol of γ-butyrolactone and 4 mol of liquid methylamine were added, and the mixture was sealed and heated at ° C. For 4 hours. After cooling, Excess methylamine was released, and distillation was carried out to collect the 201-202 ° C. Fraction to obtain about 180g of the product in a yield of about 90%. Raw material consumption (kg/g)γ-butyrolactone 980 methylamine (40%) 860 |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 3914 mg/kg; Oral-mouse LD50: 5130 mg/kg |
| stimulation data | eye-rabbit 100 mg moderate |
| flammability hazard characteristics | flammable in open flame, high temperature, strong oxidant; thermal decomposition of toxic nitric oxide gas |
| storage and transportation characteristics | The package is complete, light, light; The warehouse is ventilated, away from open flame, high temperature, separate from oxidant |
| fire extinguishing agent | foam, carbon dioxide, dry powder, sand |
| Occupational Standard | TWA 100 PPM (400 mg/m3); sel 100 mg/m3 |
| spontaneous combustion temperature | 518 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:53
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View History
N-甲基吡咯烷酮(NMP)
邻异丙氧基苯亚甲基二氯(三环己基膦)合钌
利培酮EP杂质A
2-[(4,4-二乙氧基-2-丁炔-1-基)氧基]四氢吡喃
1,1-Diphenyl-2-picrylhydrazyl (DPPH)
CCRIS 3349
HO-PEG2-t-Butyl ester
TIMOLOL HYDROGENMALEATE
5-溴-6-氨基吡啶-2-甲酸甲酯
N-ALPHA-FMOC-4-(膦酰基二氟甲基)-L-苯基丙氨酸
邻异丙氧基苯亚甲基二氯(三环己基膦)合钌
利培酮EP杂质A
2-[(4,4-二乙氧基-2-丁炔-1-基)氧基]四氢吡喃
1,1-Diphenyl-2-picrylhydrazyl (DPPH)
CCRIS 3349
HO-PEG2-t-Butyl ester
TIMOLOL HYDROGENMALEATE
5-溴-6-氨基吡啶-2-甲酸甲酯
N-ALPHA-FMOC-4-(膦酰基二氟甲基)-L-苯基丙氨酸
Raw Materials for N-甲基吡咯烷酮(NMP)