N6-Methyladenosine
6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
CAS: 1867-73-8
Molecular Formula: C11H15N5O4
N6-Methyladenosine - Names and Identifiers
N6-Methyladenosine - Physico-chemical Properties
| Molecular Formula | C11H15N5O4 |
| Molar Mass | 281.27 |
| Density | 1.85±0.1 g/cm3(Predicted) |
| Melting Point | 172 °C |
| Boling Point | 649.1±65.0 °C(Predicted) |
| pKa | 13.12±0.70(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Physical and Chemical Properties | Bioactive N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) are base-modified adenosine analogs that act as rare nucleosides in native RNAs. N6-methyladenosine(m6A) is the fifth base of mRNA. |
| In vitro study | N6-Methyladenosine is an abundant base-Modified Adenosine analog of mRNA found in some Virus and most eukaryotes, including mammals, insects, plants and yeasts. It is also found in tRNA,rRNA, and small nuclear RNA(snRNA) as well as some long non-coding RNAs such as Xist. N6-Methyladenosine is an endogenous urinary nucleoside product that is degraded by transport ribonucleic acid (tRNA). In many tissues, N6-Methyladenosine are widespread RNA modifications, especially at higher levels in the brain. N6-Methyladenosine is enriched in mouse and human mRNAs near the stop codon and within the 3 'UTRS. Recent studies have found that FTO, an obesity risk gene, encodes m6A demethylase, which is a regulator of important physiological processes. |
| In vivo study | LD50: mice> 1 g/kg (Gavage). |
N6-Methyladenosine - Upstream Downstream Industry
| Downstream Products | Adenosine, N-methyl-3'-O-methyl- (9CI) N(6),O(2)-Dimethyladenosine |
N6-Methyladenosine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.364 ml | 16.82 ml | 33.64 ml |
| 5 mM | 0.673 ml | 3.364 ml | 6.728 ml |
| 10 mM | 0.336 ml | 1.682 ml | 3.364 ml |
| 5 mM | 0.067 ml | 0.336 ml | 0.673 ml |
Last Update：2024-01-02 23:10:35
N6-Methyladenosine - Introduction
6-METHYLAMINOPURINE 9-ribofuanoside is a chemical substance that belongs to the nucleoside class of compounds. The following is a description of its nature, use, preparation and safety information:
Nature:
6-METHYLAMINOPURINE 9-ribofuanoside is a white crystalline solid that is stable at room temperature. Its molecular formula is C11H15N5O4 and its molecular weight is 297.27. It has good solubility and can be dissolved in water, alcohols and ketones.
Use:
6-METHYLAMINOPURINE 9-ribofuanoside is commonly used in biomedical research, especially in the fields of nucleic acid chemistry, protein translation, and cell signaling. It has important application value in the study of cell and molecular biology.
Preparation Method:
6-METHYLAMINOPURINE 9-ribofuanoside can be prepared through a series of chemical reactions. One common method is to react adenosine with a methylating agent, such as by methyl carbonate or direct use of MeI (methyl iodide).
Safety Information:
6-METHYLAMINOPURINE 9-ribofuanoside should be used in the laboratory in accordance with the relevant safety procedures. It may pose a certain risk to human health, so it is necessary to pay attention to protective measures during use, such as wearing protective gloves, glasses and laboratory coats. In addition, avoid inhalation or skin contact, and keep away from ignition and flammable materials.
Nature:
6-METHYLAMINOPURINE 9-ribofuanoside is a white crystalline solid that is stable at room temperature. Its molecular formula is C11H15N5O4 and its molecular weight is 297.27. It has good solubility and can be dissolved in water, alcohols and ketones.
Use:
6-METHYLAMINOPURINE 9-ribofuanoside is commonly used in biomedical research, especially in the fields of nucleic acid chemistry, protein translation, and cell signaling. It has important application value in the study of cell and molecular biology.
Preparation Method:
6-METHYLAMINOPURINE 9-ribofuanoside can be prepared through a series of chemical reactions. One common method is to react adenosine with a methylating agent, such as by methyl carbonate or direct use of MeI (methyl iodide).
Safety Information:
6-METHYLAMINOPURINE 9-ribofuanoside should be used in the laboratory in accordance with the relevant safety procedures. It may pose a certain risk to human health, so it is necessary to pay attention to protective measures during use, such as wearing protective gloves, glasses and laboratory coats. In addition, avoid inhalation or skin contact, and keep away from ignition and flammable materials.
Last Update：2024-04-10 22:29:15
N6-Methyladenosine - Uses and synthesis methods
Target
Human Endogenous Metabolite
in vitro studies
N6-Methyladenosine is a rich base modified adenosine analog in mRNA, found in some viruses and most eukaryotes, including mammals, insects, plants and yeast. It is also found in tRNA,rRNA, and small nuclear RNA(snRNA) as well as some long-chain non-coding RNA, such as Xist. N6-Methyladenosine is an endogenous uridine product that transports ribonucleic acid (tRNA) degradation. In many tissues, N6-Methyladenosine are widely present RNA modifiers, especially in the brain with high levels. N6-Methyladenosine are enriched near mouse and human mRNAs stop codons and within 3'UTRs. Recent studies have found that FTO, an obesity risk gene, encodes m6A demethylase, which is an important regulator of physiological processes.
In vivo studies
LD50: mice> 1 g/kg (gavage).
Last Update：2024-04-09 21:54:55
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Multiple SpecificationsSpot supply
Product Name: N6-Methyladenosine (Standard) Visit Supplier Webpage Request for quotationCAS: 1867-73-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 6-methylaminoqurine 9-ribofuranoside Visit Supplier Webpage Request for quotationCAS: 1867-73-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
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Product Name: N6-Methyladenosine Visit Supplier Webpage Request for quotationCAS: 1867-73-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: N6-Methyladenosine Visit Supplier Webpage Request for quotationCAS: 1867-73-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Visit Supplier Webpage Request for quotationCAS: 1867-73-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
N6-Methyladenosine
三苯甲基四(五氟苯基)硼酸盐
2,5-二甲基环己酮(异构体的混合物)
硝苯地平杂质7(顺式和反式异构体的混合物)
1-(3-溴-4-甲基苯基)乙醇
2-[[[4-(3-甲氧基丙氧基)-3-甲基嘧啶-2-基]甲基]硫代]-1H-苯并咪唑
三(乙烯醇) 单-11-十一烷基硫醇
CHOLINE HYDROGEN CARBONATE
三苯甲基四(五氟苯基)硼酸盐
2,5-二甲基环己酮(异构体的混合物)
硝苯地平杂质7(顺式和反式异构体的混合物)
1-(3-溴-4-甲基苯基)乙醇
2-[[[4-(3-甲氧基丙氧基)-3-甲基嘧啶-2-基]甲基]硫代]-1H-苯并咪唑
三(乙烯醇) 单-11-十一烷基硫醇
CHOLINE HYDROGEN CARBONATE
Downstream Products for N6-Methyladenosine