NU1025
8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE
CAS: 90417-38-2
Molecular Formula: C9H8N2O2
NU1025 - Names and Identifiers
NU1025 - Physico-chemical Properties
| Molecular Formula | C9H8N2O2 |
| Molar Mass | 176.17 |
| Density | 1.42 |
| Melting Point | 253-258°C |
| Solubility | Soluble in DMSO |
| Appearance | Form solid, color off-white |
| Storage Condition | −20°C |
| Physical and Chemical Properties | Bioactive NU1025 (NSC 696807) is an effective PARP inhibitor with IC50 of 400 nM. |
| Use | NU1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1025 enhanced the cytotoxicity of the DNA-methylating agent MTIC, gamma-irradiation and bleomycin 3.5-, 1.4- and 2-fold respectively. |
| Target | IC50: 400 nM (PARP) Ki: 48 nM (PARP) |
NU1025 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29335990 |
NU1025 - Upstream Downstream Industry
NU1025 - Reference
| Reference Show more | 1: Kaundal RK, Shah KK, Sharma SS. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sci. 2006 Nov 10;79(24):2293-302. Epub 2006 Aug 2. PubMed PMID: 16935310. 2: Bowman KJ, Newell DR, Calvert AH, Curtin NJ. Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. Br J Cancer. 2001 Jan 5;84(1):106-12. PubMed PMID: 11139322; PubMed Central PMCID: PMC2363607. 3: Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br J Cancer. 1998 Nov;78(10):1269-77. PubMed PMID: 9823965; PubMed Central PMCID: PMC2063197. |
NU1025 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.676 ml | 28.382 ml | 56.763 ml |
| 5 mM | 1.135 ml | 5.676 ml | 11.353 ml |
| 10 mM | 0.568 ml | 2.838 ml | 5.676 ml |
| 5 mM | 0.114 ml | 0.568 ml | 1.135 ml |
Last Update：2024-01-02 23:10:35
NU1025 - Cell Experiment
Cell lines: D54 and U251 cellsConcentrations: 160 μMIncubation Time: 5 daysMethod: Cells are seeded in 96-well plates at a density of 2,500 cells/well and treated with the indicated doses of NU1025. Adherent cells are irradiated in medium with 250 kVp X-rays (dose rate 0.5 Gy/min). Untreated cells are used as a control. Following an up to 5 day incubation, cell proliferation is assessed by MTT assay.
Last Update：2023-08-16 21:32:38
NU1025 - Animal Experiment
Animal Models: Male Sprague Dawley ratsDosages: 3 mg/kgAdministration: i.p.
Last Update：2023-08-16 21:32:38
NU1025 - Nature
| solubility | DMSO: 35 mg/mL, soluble |
Last Update：2024-04-10 22:29:15
NU1025 - Uses and synthesis methods
in vitro study
NU1025(0.2 mM) treatment can reduce H2O2-induced cytotoxicity. NU1025 itself had no effect on cell activity. In cells treated with SIN-1(0.8 mM), NU1025 pretreatment can significantly increase cell survival rate (82.59±4.67%). NU1025 had no detectable pro-proliferative effect in D54 and U251 cells. NU1025 can significantly inhibit the promotion of TPT and RT on PARP-1 activity. No DNA strand breaks were detected after 200 μM NU1025 treatment alone.
in vivo studies
Rats treated with NU1025(1 and 3 mg/kg) can reduce 25% and 45% infarction respectively compared with solvent group. NU1025(1 and 3 mg/kg) treatment can significantly reduce edema volume. NU1025 can significantly improve neurological damage.
Last Update：2024-04-09 21:01:54
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Spot supply
Product Name: NU1025 Visit Supplier Webpage Request for quotationCAS: 90417-38-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for NU1025
Sodium hydroxide
Methanol
Tetrahydrofuran
N,N-Dimethylformamide
Thionyl chloride
Magnesium sulfate
Ethyl acetoacetate
3-METHOXY-2-NITROBENZOIC ACID
Methanol
Tetrahydrofuran
N,N-Dimethylformamide
Thionyl chloride
Magnesium sulfate
Ethyl acetoacetate
3-METHOXY-2-NITROBENZOIC ACID