| Name | NEBRACETAM |
| Synonyms | WEB-1881 NEBRACETAM WEB-1881FU Nebracetamum Unii-T30038qi8n Nebracetamum [inn-latin] (±)-4-(Aminomethyl)-1-(phenylmethyl)-2-pyrrolidinone |
| CAS | 116041-13-5 |
| Molecular Formula | C12H16N2O |
| Molar Mass | 204.271 |
| Physical and Chemical Properties | Chemical Properties Nairacetam Fumarate (Nebracetam Fumarate):(C12H16N2O)2?C4H4O4. [97205-35-1]. Crystallization, melting point 192~194 ℃. Acute toxicity LD50 male and female rats (mg/kg):257,257 intravenous injection; 2884,3622 oral. |
| Use | Use of nootropic drugs. It has a cholinergic effect and has an affinity for cholinergic receptors, especially for M1, the receptor. |
| Raw Materials | Fumaric acid |
Method 1: Compound (I) and thionyl chloride are refluxed in methylene chloride to form chloride (II). Then it is condensed with potassium phthalamide in dimethylformamide, and the product (III) is reduced with hydrazine in ethanol to obtain nelacetam, which is neutralized with fumaric acid to obtain nelacetam fumarate.
Method 2: Compound (Ⅳ) is reacted with phosphorus oxychloride in hot dimethylformamide to dehydrate to obtain nitrile (V), and then hydrogenated and reduced under the catalysis of Raney nickel in ammonia-methanol mixture to obtain nelacetam, and neutralized with fumaric acid to obtain nelacetam fumarate.