PENTAMETHYLENETETRAZOLE

Name	1,5-Pentamethylenetetrazole
Synonyms	METRAZOLE CARDIAZOLE Pentylene tetrazole PENTAMETHYLENETETRAZOLE 1,5-Pentamethylenetetrazole 1,5-PENTAMETHYLENETETRAZOLE 1,5-PENTAMETHYLENE-1H-TETRAZOLE 6,7,8,9-TETRAHYDRO-5H-TETRAZOLOAZEPINE ALPHA,BETA-CYCLOPENTAMETHYLENETETRAZOLE 6,7,8,9-TETRAHYDRO-5H-TETRAZOLO-[1,5-A]AZEPINE
CAS	54-95-5
EINECS	200-219-3
InChI	InChI=1/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
InChIKey	CWRVKFFCRWGWCS-UHFFFAOYSA-N

Molecular Formula	C6H10N4
Molar Mass	138.17
Density	1.0617 (rough estimate)
Melting Point	59-61 °C (lit.)
Boling Point	194 °C/12 mmHg (lit.)
Flash Point	194°C/12mm
Water Solubility	>=10 g/100 mL at 21 C
Vapor Presure	9.27E-05mmHg at 25°C
Color	White, crystalline powder
Merck	14,7141
BRN	135492
pKa	1.25±0.20(Predicted)
Storage Condition	-20°C
Stability	Stable. Incompatible with strong oxidizing agents.
Sensitive	Hygroscopic
Refractive Index	1.4910 (estimate)
In vivo study	In almost all rats, a single intraperitoneal injection of Pentylenetetrazol(45 mg/kg) induced a clonic convulsion within 3 min. However, 11% of the rats required a second injection for clonus/cramps. Each rat developed muscle twitching and myoclonus after a clonic or tonic-clonic seizure. Injection of Pentylenetetrazol significantly changed the mRNA levels of the GABAA receptor subunits. Clonus elicited by a single injection of PTZ was correlated with rapid changes in GABAA receptors.

Hazard Symbols	T - Toxic
Risk Codes	R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	XF8225000
TSCA	Yes
Hazard Class	6.1
Packing Group	II
Toxicity	LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal)

NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
biological activity	Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) are stimulants of the central nervous system and respiratory system. It is a non-competitive GABA(A) receptor antagonist.
Target	Value

Last Update：2024-04-10 22:29:15

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