PHOSPHOMYCIN
fosfomycin
CAS: 23155-02-4
Molecular Formula: C3H7O4P
PHOSPHOMYCIN - Names and Identifiers
| Name | fosfomycin |
| Synonyms | mk-955 fosfocina FOSFOMYCIN fosfomycin fosfonomycin PHOSPHOMYCIN (3-Methyloxiran-2-yl)phosphonic acid [(3S)-3-methyloxiran-2-yl]phosphonic acid Phosphonic acid, (2R,3S)-3-methyloxiranyl- [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid |
| CAS | 23155-02-4 |
| EINECS | 245-463-1 |
| InChI | InChI=1/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1 |
PHOSPHOMYCIN - Physico-chemical Properties
| Molecular Formula | C3H7O4P |
| Molar Mass | 138.06 |
| Density | 1.56±0.1 g/cm3(Predicted) |
| Melting Point | 94°C |
| Boling Point | 342.7±52.0 °C(Predicted) |
| Flash Point | 161.03°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | solid |
| pKa | 3.20±0.40(Predicted) |
| Refractive Index | 1.486 |
| Physical and Chemical Properties | Crystals with a melting point of about 94 °c. Clinical general use of its sodium or calcium salt, sodium salt for injection, calcium salt for oral use. Its sodium salt is white crystalline powder, with strong hygroscopicity, easily soluble in water, slightly soluble in ethanol, ether and other organic solvents. Its calcium salt is white powder, slightly soluble in water, insoluble in acetone, benzene, chloroform and ether. |
| Use | Has a good effect on Pseudomonas aeruginosa, Proteus, Escherichia coli, Serratia and Staphylococcus |
PHOSPHOMYCIN - Upstream Downstream Industry
| Raw Materials | Acetophenone Phosphorus trichloride |
PHOSPHOMYCIN - Reference Information
| use effect | for us, this is an alternative treatment." Dr Ilias Karaiskos, a Greek research leader, said, "We think if we have quinolones available, then we should use quinolones, because many studies have shown that quinolones are fully effective in the prostate and have the strongest ability to enter prostate tissue. But if the pathogenic microorganism in the patient's body is resistant to quinolones, then I will use fosfomycin. |
| use | this product is a broad-spectrum antibiotic, which plays a bactericidal role by preventing the synthesis of bacterial cell walls, and is effective for both gram-half positive and negative bacteria. Mainly used for Staphylococcus aureus, Dandobacterium, Proteus mirabilis, Shigella and other infections. It has a good effect on Pseudomonas aeruginosa, Proteus, Escherichia coli, Serratia and Staphylococcus. |
| production method | using propargyl alcohol as raw material, through esterification, rearrangement, hydrolysis, isomerization, disodium propynyl phosphate. Then it is hydrolyzed, isomerized, and hydrogenated to obtain cis-propylene phosphoric acid. Pisacryl phosphoric acid is salted with (±)-a-phenethylamine, epoxidation, and resolution to obtain fosfomycin. |
Last Update：2024-04-09 15:16:44
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