PT2385
PT2385
CAS: 1672665-49-4
Molecular Formula: C17H12F3NO4S
PT2385 - Names and Identifiers
PT2385 - Physico-chemical Properties
| Molecular Formula | C17H12F3NO4S |
| Molar Mass | 383.34 |
| Density | 1.57±0.1 g/cm3(Predicted) |
| Boling Point | 524.7±50.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 11.28±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | PT2385 prevents the dimerization of HIF-2α with ARNT/HIF1β. In ccRCC cell lines and xenograft models, PT2385 inhibition is dependent on HIF2α gene expression, including VEGF-A, PAI-1, and cyclin D1. At a concentration of 10 μm, PT2385 had no effect on the proliferation and viability of 786-O and A498 cells. Treatment of 786-O cells with PT2385 significantly reduced the levels of CCND1, VEGF-A, GLUT1 and PAI-1 mRNA. Treatment of Hep3B cells with PT2385 reduced hypoxia-induced erythropoietin and PAI-1 expression. |
| In vivo study | PT2385 has high oral bioavailability (110%) with low-moderate in vivo clearance in mice. The half-life of PT2385 was 3.3 h by intravenous administration to mice. A pharmacokinetic study was carried out in rats and the oral bioavailability of 10 mg/kg PT2385 was 40% with a half-life of 3.3 hours. In dogs, PT2385 has an oral bioavailability of 87% and a half-life of 11 hours. Treatment of tumor-bearing mice (clear cell renal cell carcinoma) with PT2385 resulted in significant tumor regression. PT2385 had no adverse effects on cardiovascular function. |
PT2385 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.609 ml | 13.043 ml | 26.086 ml |
| 5 mM | 0.522 ml | 2.609 ml | 5.217 ml |
| 10 mM | 0.261 ml | 1.304 ml | 2.609 ml |
| 5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Last Update：2024-01-02 23:10:35
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Product Name: PT-2385 Visit Supplier Webpage Request for quotationCAS: 1672665-49-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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