Pinostilbene
Pinostilbene
CAS: 42438-89-1
Molecular Formula: C15H14O3
Pinostilbene - Names and Identifiers
| Name | Pinostilbene |
| Synonyms | Pistilbene Pinostilbene trans-Pinostilbene Pinostilbene hydrate trans-Pinostilbene hydrate 3-methoxy-4',5-dihydroxy-trans-stilbene 3,4'-Dihydroxy-5-methoxy-trans-stilbene 3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxyphenol 3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-methoxyphenol phenol, 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy- |
| CAS | 42438-89-1 |
| EINECS | 694-822-2 |
| InChI | InChI=1/C15H14O3/c1-18-15-9-12(8-14(17)10-15)3-2-11-4-6-13(16)7-5-11/h2-10,16-17H,1H3/b3-2+ |
Pinostilbene - Physico-chemical Properties
| Molecular Formula | C15H14O3 |
| Molar Mass | 242.27 |
| Density | 1.252 |
| Melting Point | 117-118℃ |
| Boling Point | 454.3°C at 760 mmHg |
| Flash Point | 228.5°C |
| Solubility | DMSO: ≥13mg/mL |
| Vapor Presure | 7.17E-09mmHg at 25°C |
| Appearance | Powder |
| Color | white to tan |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.691 |
| MDL | MFCD20527315 |
| In vitro study | Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells. Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells. Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells. Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis. Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Cell Viability Assay Cell Line: HCT116 cells, HT29 cells Concentration: 24 hours, 48 hours Incubation Time: 0-100 μM Result: Inhibited the growth of two human colon cancer cells. Apoptosis Analysis Cell Line: HCT116 cells, HT29 cells Concentration: 20 μM, 40 μM Incubation Time: 24 hours, 48 hours Result: Caused a significant and dose-dependent increase in the percentage of cells in S phase. Cell Viability Assay Cell Line: HCT116 cells Concentration: 20 μM,40 μM Incubation Time: 24 hours, 48 hours Result: Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21 Cip1/Waf1 , while decreased the expression levels of cyclin E and p-Rb. |
Pinostilbene - Risk and Safety
| Risk Codes | R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R50 - Very Toxic to aquatic organisms |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
Pinostilbene - Reference Information
| use | stilbene can be used for content determination and is not used for other purposes. |
| biological activity | Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene has inhibitory effect on colon cancer cells. |
| in vitro study | Pinostilbene (0-40μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells. Pinostilbene (20 μ m, 40 μ m; 24 hours, 48 hours) cause a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells. Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells. Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis. Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Cell Viability Assay Cell Line: HCT116 cells, HT29 cells Concentration: 24 hours, 48 hours Incubation Time: 0-100μM Result: Inhibited the growth of two human colin cancer cells. Apoptosis Analysis Cell Line: HCT116 cells, HT29 cells Concentration: 20 μ m, 40 μ m Incubation time: 24 hours, 48 hours result: used a significant and dose-dependent increase in the percentage of cells in s phase. cell Viability assaycell line: hct116 cells Concentration: 20 μ m, 40 μ m Incubation time: 24 hours, 48 hours result: Significantly increased the expression levels of p53, bax, cleaved caspase-3, cleaved PARP and p21 Cip1/Waf1 , while decreased the expression levels of cyclin e and p-Rb. |
| Cell Line: | HCT116 cells, HT29 cells HCT116 cells, HT29 cells HCT116 cells |
| Concentration: | 24 hours, 48 hours 20 μM, 40 μM 20 μM,40 μM |
| Incubation Time: | 0-100 μM 24 hours, 48 hours 24 hours, 48 hours |
| Result: | Inhibited the growth of two human colon cancer cells. Caused a significant and dose-dependent increase in the percentage of cells in S phase. Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21 Cip1/Waf1 , while decreased the expression levels of cyclin E and p-Rb. |
Last Update：2024-04-10 22:29:15
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