Pramipexole
Pramipexole
CAS: 104632-26-0
Molecular Formula: C10H17N3S
Pramipexole - Names and Identifiers
| Name | Pramipexole |
| Synonyms | Sifrol SND-919 Oprymea U-98528E Mirapexin Pramipexol SUD919CL2Y Pramipexole Pramipexolum UNII-83619PEU5T (S)-Pramipexole (-)-Pramipexole Pramipexole Teva Pramipexolum [Latin] Pramipexol [Spanish] Pramipexole free base (S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole (S)-4,5,6,7-Tetrahydro-N'-propylbenzothiazole-2,6-diamine (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole (S)-6-(Propylamino)-4,5,6,7-tetrahydrobenzothiazole-2-amine (6S)-N'-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6α-diamine 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)- (6S)-4,5,6,7-Tetrahydro-2-amino-6α-(propylamino)benzothiazole 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)- |
| CAS | 104632-26-0 |
| EINECS | 600-593-1 |
| InChI | InChI=1/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m1/s1 |
Pramipexole - Physico-chemical Properties
| Molecular Formula | C10H17N3S |
| Molar Mass | 211.33 |
| Density | 1.17±0.1 g/cm3(Predicted) |
| Melting Point | 288-290°C |
| Boling Point | 378.0±42.0 °C(Predicted) |
| Solubility | DMSO 42 mg/mL Water <1 mg/mL Ethanol 42 mg/mL |
| Appearance | White to white-like powder |
| Color | White to Off-White |
| pKa | 9.47±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| MDL | MFCD00869076 |
| Physical and Chemical Properties | Pramipexole Dihydrochloride: C10H17N3S? 2HCl. [104632-25-9]. Crystallization from methanol, melting point 296-298 °c. [Α] D20>-67.2 °(C = 1, methanol). |
Pramipexole - Reference Information
| biological activity | Pramipexole (SND 919) is a partial/total D2S, D2L, D3, D4 receptor agonist that acts on D2S, D2L, D3, D4 receptors, Ki is 3.9, 2.2, 0.5 and 5.1 nM respectively. |
| Target | Value |
| D3 receptor | 0.5 nM(Ki) |
| D2L Receptor | 2.2 nM(Ki) |
| D2S Receptor | 3.9 nM(Ki) |
| D4 receptor | 5.1 nM(Ki) |
| use | dopamine D2 receptor antagonist. For the treatment of Parkinson's disease. |
| production method | 0.02mol 2,6-diamino -4,5,6,7-tetrahydrobenzothiazole is dissolved in 34ml DMF, 0.022mol n-propanal is added, and heated at 50 ℃ for 1h. Cooling, adding 0.02mol sodium borohydride, heating at 50 ℃ for 30min. Most of the solvent is distilled under reduced pressure, the remainder is dissolved in 20ml of water, and the Ph value is adjusted to 1 with 2mol/L hydrochloric acid. The water layer was extracted with ethyl acetate, and the extract and organic layer were discarded. Potassium carbonate was added to the water layer until alkaline, then extracted with ethyl acetate, the extract was dried and concentrated, and the ether solution containing HCl was added to obtain pramipexole dihydrochloride with 42% yield and 286-288 ℃ melting point. 4-Propaminocyclohexanone (I) is brominated with hydrobromic acid in acetic acid, the product (II) is condensed with thiourea, and then acidified to obtain pramipexole dihydrochloride. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:32:03
Supplier List
Product Name: Pramipexole Monomer Request for quotation
CAS: 104632-26-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 104632-26-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Pramipexole Request for quotation
CAS: 104632-26-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 104632-26-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Pramipexole Visit Supplier Webpage Request for quotationCAS: 104632-26-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Pramipexole Monomer Request for quotation
CAS: 104632-26-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 104632-26-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Pramipexole Request for quotation
CAS: 104632-26-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 104632-26-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Pramipexole Visit Supplier Webpage Request for quotationCAS: 104632-26-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History