RVX-208
2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one
CAS: 1044870-39-4
Molecular Formula: C20H22N2O5
RVX-208 - Names and Identifiers
RVX-208 - Physico-chemical Properties
| Molecular Formula | C20H22N2O5 |
| Molar Mass | 370.4 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Boling Point | 594.2±60.0 °C(Predicted) |
| Appearance | Form solid, color White |
| pKa | 14.21±0.10(Predicted) |
| Storage Condition | -20°C (des.) |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Physical and Chemical Properties | Bioactive RVX-208 is an effective BET bromodomain inhibitor, acting on BD2 with IC50 of 0.510 μM, which is 170 times more selective than acting on BD1. Phase 2. |
RVX-208 - Upstream Downstream Industry
RVX-208 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.7 ml | 13.499 ml | 26.998 ml |
| 5 mM | 0.54 ml | 2.7 ml | 5.4 ml |
| 10 mM | 0.27 ml | 1.35 ml | 2.7 ml |
| 5 mM | 0.054 ml | 0.27 ml | 0.54 ml |
Last Update：2024-01-02 23:10:35
RVX-208 - Uses and synthesis methods
in vitro studies
As a BET bromine domain protein inhibitor, the RVX-208 preferentially binds to the second bromine domain protein based on the BET protein. RVX-208, as an agonist of apolipoprotein (APO) AI gene expression, increased apoA-I and HDL-C in vitro.
In vivo studies
RVX-208 significantly increased serum apoA-I and HDL-C in AGMs, and increased cholesterol outflow through different routes.
Features
The first new drug BD2 selective BET bromine domain protein inhibitor was tested in a phase II clinical trial for the treatment of coronary syndrome and atherosclerosis.
Last Update：2024-04-09 21:01:54
Supplier List
Spot supply
Product Name: Apabetalone Visit Supplier Webpage Request for quotationCAS: 1044870-39-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Apabetalone Visit Supplier Webpage Request for quotationCAS: 1044870-39-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for RVX-208
Benzonitrile, 2-amino-4,6-dimethoxy-
3,5-Dimethyl-4-hydroxybenzaldehyde
4-(2-hydroxyethoxy)-3,5-dimethylbenzaldehyde
2-AMINO-4,6-DIMETHOXY-BENZOIC ACID
1-Bromo-3,5-dimethoxybenzene
3,5-Dimethoxybenzoic acid
3,5-Dihydroxybenzoic acid
3,5-Dimethyl-4-hydroxybenzaldehyde
4-(2-hydroxyethoxy)-3,5-dimethylbenzaldehyde
2-AMINO-4,6-DIMETHOXY-BENZOIC ACID
1-Bromo-3,5-dimethoxybenzene
3,5-Dimethoxybenzoic acid
3,5-Dihydroxybenzoic acid