Name | Amorolfine |
Synonyms | Fradafi SYLIMARIN AMOROLFINE Fradafiban Amorolfine (2R,6S)-4-[3-(4-tert-amylphenyl)-2-methyl-propyl]-2,6-dimethyl-morpholine cis-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine (2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine |
CAS | 67467-83-8 78613-35-1 |
EINECS | 1312995-182-4 |
InChI | InChI=1/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+ |
Molecular Formula | C21H35NO |
Molar Mass | 317.51 |
Density | 0.924±0.06 g/cm3(Predicted) |
Boling Point | 407.1±33.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Appearance | Oil |
Color | Colourless |
pKa | 7.33±0.10(Predicted) |
Storage Condition | Refrigerator, under inert atmosphere |
Use | Antifungal Agents for external use, which have a different mechanism of action from other existing antifungal agents, inhibit two enzymes in ergosterol biosynthesis, reductase and isomerase. In vitro has a very high antifungal activity, in vivo activity is better than naftifine, clotrimazole, oxiconazole and ketoconazole, a variety of fungal skin disease caused by Recovery Rate more than 85%, there are effects on onychomycosis |