TRIMETHYLSILYL(TRIMETHYLSILOXY)ACETATE
Trimethylsilyl(trimethylsiloxy)acetate
CAS: 33581-77-0
Molecular Formula: C8H20O3Si2
TRIMETHYLSILYL(TRIMETHYLSILOXY)ACETATE - Names and Identifiers
TRIMETHYLSILYL(TRIMETHYLSILOXY)ACETATE - Physico-chemical Properties
| Molecular Formula | C8H20O3Si2 |
| Molar Mass | 220.41 |
| Density | 0.903g/mLat 25°C(lit.) |
| Boling Point | 82-83°C15mm Hg |
| Flash Point | 110°F |
| Vapor Presure | 1.09mmHg at 25°C |
| Specific Gravity | 0.918 |
| BRN | 2045011 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | 7: reacts slowly with moisture/water |
| Refractive Index | n20/D 1.411(lit.) |
TRIMETHYLSILYL(TRIMETHYLSILOXY)ACETATE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 3272 3/PG 3 |
| WGK Germany | 2 |
| FLUKA BRAND F CODES | 21 |
| TSCA | No |
| Hazard Class | 3.2 |
| Packing Group | III |
TRIMETHYLSILYL(TRIMETHYLSILOXY)ACETATE - Introduction
Trimethylsilyl(trimethylsiloxy)acetate, abbreviated as TMSA, is an organosilicon compound. The following is an introduction to the nature, use, formulation and safety information of TMSA:
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in common organic solvents such as ethers, alcohols and esters
-Melting point:-80 ° C
-Boiling point: about 130 ° C
-Molecular formula: C9H22O4Si3
-Molecular weight: 262.53g/mol
Use:
- TMSA is commonly used as a reagent in organic synthesis, and can be used as an esterification agent, an acid catalyst and a protecting group in organic synthesis.
-In organic synthesis, TMSA can be used to synthesize alcohols, phenols and ether compounds.
-As a protecting group, TMSA can protect functional groups such as alcohols, phenols and ethers to prevent them from being changed or destroyed in chemical reactions.
- TMSA can also be used for the direct synthesis of ketones in organic synthesis.
Method:
The preparation of TMSA is usually carried out by the following steps:
1. Isopropyllithium (i-PrLi) is reacted with trimethylsilyl chloride (Me3SiCl) to produce trimethylsilyl lithium (Me3SiLi).
2. Trimethylsilanol acetate (Me3SiOAc) was obtained by reacting lithium trimethylsilane with acetic anhydride (Ac2O).
3. Reacting trimethylsilanol acetate with ethanol to obtain TMSA.
Safety Information:
- TMSA is generally stable and safe under normal operating and storage conditions.
-It is not flammable, but it can decompose when heated or in contact with oxygen to produce harmful gases.
-Avoid contact with skin and eyes when using TMSA, and ensure that it is operated in a well-ventilated place.
-Please handle and store the TMSA in accordance with proper laboratory practices and safety regulations.
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in common organic solvents such as ethers, alcohols and esters
-Melting point:-80 ° C
-Boiling point: about 130 ° C
-Molecular formula: C9H22O4Si3
-Molecular weight: 262.53g/mol
Use:
- TMSA is commonly used as a reagent in organic synthesis, and can be used as an esterification agent, an acid catalyst and a protecting group in organic synthesis.
-In organic synthesis, TMSA can be used to synthesize alcohols, phenols and ether compounds.
-As a protecting group, TMSA can protect functional groups such as alcohols, phenols and ethers to prevent them from being changed or destroyed in chemical reactions.
- TMSA can also be used for the direct synthesis of ketones in organic synthesis.
Method:
The preparation of TMSA is usually carried out by the following steps:
1. Isopropyllithium (i-PrLi) is reacted with trimethylsilyl chloride (Me3SiCl) to produce trimethylsilyl lithium (Me3SiLi).
2. Trimethylsilanol acetate (Me3SiOAc) was obtained by reacting lithium trimethylsilane with acetic anhydride (Ac2O).
3. Reacting trimethylsilanol acetate with ethanol to obtain TMSA.
Safety Information:
- TMSA is generally stable and safe under normal operating and storage conditions.
-It is not flammable, but it can decompose when heated or in contact with oxygen to produce harmful gases.
-Avoid contact with skin and eyes when using TMSA, and ensure that it is operated in a well-ventilated place.
-Please handle and store the TMSA in accordance with proper laboratory practices and safety regulations.
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: bis(Trimethylsilyl)glycolate Visit Supplier Webpage Request for quotationCAS: 33581-77-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Trimethylsilyl 2-((trimethylsilyl)oxy)acetate Visit Supplier Webpage Request for quotationCAS: 33581-77-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: Trimethylsilyl(Trimethylsiloxy)Acetate Visit Supplier Webpage Request for quotation
CAS: 33581-77-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 33581-77-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: bis(Trimethylsilyl)glycolate Visit Supplier Webpage Request for quotationCAS: 33581-77-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Trimethylsilyl 2-((trimethylsilyl)oxy)acetate Visit Supplier Webpage Request for quotationCAS: 33581-77-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: Trimethylsilyl(Trimethylsiloxy)Acetate Visit Supplier Webpage Request for quotation
CAS: 33581-77-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 33581-77-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
TRIMETHYLSILYL(TRIMETHYLSILOXY)ACETATE
4-Hydroxy-beta-phenylethylamine
二甲氨亚甲基丙二酸二乙酯
Propane, 1-isothiocyanato-2-methyl- (9CI)
(1-戊基)三苯基溴化磷鎓
LEMON OIL SPANISH
2-环丙基噻唑-5-甲醛
6-溴-2-苯基-4H-苯并[D][1,3]噁嗪-4-酮
降钙素基因相关肽片段
7,8-二氢-6H-异喹啉-5-酮
4-Hydroxy-beta-phenylethylamine
二甲氨亚甲基丙二酸二乙酯
Propane, 1-isothiocyanato-2-methyl- (9CI)
(1-戊基)三苯基溴化磷鎓
LEMON OIL SPANISH
2-环丙基噻唑-5-甲醛
6-溴-2-苯基-4H-苯并[D][1,3]噁嗪-4-酮
降钙素基因相关肽片段
7,8-二氢-6H-异喹啉-5-酮