Tasquinimod

Name	Tasquinimod
Synonyms	ABR-215050 tasquinimod Tasquinimod 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-c 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-trifluoromethyl)phenyl]-3-quinolinecarboxamide 3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-5-Methoxy-N,1-diMethyl-2-oxo-N-[4-(trifluoroMethyl)phenyl]- N-Methyl-N-(4-trifluoromethylphenyl)-1,2-dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxoquinoline-3-carboxamide 4-Hydroxy-5-methoxy-N-methyl-1-methyl-2-oxo-N-(4-trifluoromethylphenyl)-1,2-dihydroquinoline-3-carboxamide 4-Hydroxy-5-Methoxy-1-Methyl-2-oxo-1,2- dihydro-quinoline-3-carboxylic acid Methyl- (4-trifluoroMethyl-phenyl)-aMide
CAS	254964-60-8

Molecular Formula	C20H17F3N2O4
Molar Mass	406.36
Density	1.427±0.06 g/cm3(Predicted)
Boling Point	501.5±50.0 °C(Predicted)
pKa	4.50±1.00(Predicted)
Storage Condition	2-8°C
In vitro study	Tasquinimod inhibits tumor angiogenesis through allosteric inhibition of HDAC4/N-CoR/HDAC3-dependent HIF-1α deacetylation. Tasquinimod also targets infiltrating bone marrow cells and modulates local tumor immunity by blocking the interaction of S100A9 with its ligand receptors (advanced glycation end products and Toll-like receptor 4).
In vivo study	In a mouse model of human and rodent prostate cancer, Tasquinimod (30 mg/kg/d p.o.) exhibited anti-angiogenic effects and thus inhibited tumor growth.

Last Update：2024-01-02 23:10:35

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Product Name: Tasquinimod Visit Supplier Webpage Request for quotation
CAS: 254964-60-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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Tasquinimod

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