TrimethylOrthoFormate(Tmof)

TrimethylOrthoFormate(Tmof) - Names and Identifiers

Name	Trimethyl orthoformate
Synonyms	Trimethoxymethane methoxymethanediol METHYLFORMIAT-ORTHO Methyl orthoformate Trimethylorthoformiat Trimethyl orthoformate Thrimethyl orthoformate Trimethyl ortho formate orthoformicacidmethylester TrimethylOrthoFormate(Tmof) Trimethyl Orthoformate(TMOF) Orthoformic acid trimethyl ester
CAS	149-73-5
EINECS	205-745-7
InChI	InChI:1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3
InChIKey	PYOKUURKVVELLB-UHFFFAOYSA-N

TrimethylOrthoFormate(Tmof) - Physico-chemical Properties

Molecular Formula	C4H10O3
Molar Mass	106.12
Density	0.97g/mLat 25°C(lit.)
Melting Point	-53 °C
Boling Point	101-102°C(lit.)
Flash Point	60°F
Water Solubility	10 g/L (hydrolysis)
Solubility	Miscible with ether, alcohol and benzene.
Vapor Presure	23.5 mm Hg ( 20 °C)
Vapor Density	3.67 (vs air)
Appearance	Liquid
Color	Clear colorless
Merck	14,6884
BRN	969215
Storage Condition	Store below +30°C.
Sensitive	Moisture Sensitive
Explosive Limit	1.4-44.6%(V)
Refractive Index	n20/D 1.379(lit.)
Physical and Chemical Properties	Colorless liquid. The boiling point is 103-105 ℃, the relative density is 0.967-971, the refractive index is 1.378, and the flash point is 15 ℃. Soluble in ethanol, ether, benzene, water decomposition.
Use	It is used as an intermediate for producing vitamin B1, sulfonamide drugs, antibiotics and other drugs. It is a raw material for spices and pesticides and an additive for polyurethane coatings.

TrimethylOrthoFormate(Tmof) - Risk and Safety

Risk Codes	R11 - Highly Flammable R36 - Irritating to the eyes
Safety Description	S9 - Keep container in a well-ventilated place. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S29 - Do not empty into drains.
UN IDs	UN 3272 3/PG 2
WGK Germany	1
RTECS	RM6650000
TSCA	Yes
HS Code	29159080
Hazard Class	3
Packing Group	II
Toxicity	LD50 orally in Rabbit: 3130 mg/kg

TrimethylOrthoFormate(Tmof) - Nature

Open Data Verified Data

colorless liquid. The relative density is 0. 967~971, the boiling point is 103~105 ℃, the refractive index is 1.378, and the flash point is 15 ℃. Soluble in ethanol, ether, benzene.

Last Update：2024-01-02 23:10:35

TrimethylOrthoFormate(Tmof) - Preparation Method

Open Data Verified Data

results from the reaction of chloroform and sodium methoxide.

Last Update：2022-01-01 10:33:49

TrimethylOrthoFormate(Tmof) - Use

Open Data Verified Data

for the synthesis of vitamin B1, vitamin A, sulfadiazine and pipemidic acid pharmaceutical intermediates; Also used in the dye and perfume industry.

Last Update：2022-01-01 10:33:49

TrimethylOrthoFormate(Tmof) - Safety

Open Data Verified Data

This product is an irritant article. The oral LD50 of rats is 3130mg/kg, which has a stimulating effect on the skin, eyes and mucous membranes.
This product is packed with 200kg galvanized steel drum or glass bottle external wooden box or calcium plastic box reinforcement liner. Store in a cool and ventilated warehouse, away from fire and open flame; Store and transport Isolation with oxidant to avoid sun exposure.

Last Update：2022-01-01 10:33:49

TrimethylOrthoFormate(Tmof) - Reference Information

LogP	-0.03-0.09 at 20℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	trimethyl orthoformate is used as a protecting group for aldehydes in organic synthesis and as an additive in polyurethane coatings, it is used as a dehydrating agent in the preparation of surface-modified colloidal silica nanoparticles. It is also used as a chemical intermediate for the preparation of vitamin B1 and sulfonamides. It can be used as an effective solvent for thallium (III) nitrate-mediated oxidation.
synthesis method	trimethyl orthoformate is prepared on an industrial scale by methanolysis of hydrogen cyanide: HCN 3 HOCH3 → HC(OCH3)3 NH3 trimethyl orthoformate can also be prepared from the reaction between chloroform and sodium methoxide.
Use	in the pharmaceutical industry for the production of vitamin B1, vitamin A, sulfadiazine, pipemidic acid and antibacterial agents, among them, the consumption of vitamin B1 accounted for the largest proportion of methyl formate. It is also used in the dye and fragrance industry. In the aspect of coating, it is used as a dehydrating agent to prevent hardening of polyurethane or epoxy coating due to hydration. It is used as an intermediate in the production of vitamin B1, sulfonamides, antibiotics and other drugs, and is a raw material for spices and pesticides and an additive for polyurethane coatings. Organic synthesis intermediates. Medicine is mainly used for the synthesis of vitamin B1, sulfonamides, antibiotics, etc.; Coating for the Prevention of polyurethane or epoxy coating due to hydration and hardening of the dehydrating agent; can also be used in the synthesis of perfume trimethyl orthoformate is an important intermediate in organic synthesis. Pesticides are mainly used in the synthesis of azoxystrobin, dimethyl ether and other pesticide intermediates. Medicine is mainly used for the synthesis of pipemidic acid, norfloxacin and other pharmaceutical intermediates. It is also widely used in coatings, dyes, spices and other industries.
production method	is obtained by the reaction of chloroform and methanol in the presence of caustic soda (or chloroform and sodium methoxide).
category	flammable liquid
toxicity grade	poisoning
Acute toxicity	Reference range inhalation-rat LCL0: 4000 PPM/8 h
stimulation data	Skin-rabbits 500 mg/24 h mild; eye-rabbit 100 mg moderate
flammability hazard characteristics	in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant
extinguishing agent	dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent
spontaneous combustion temperature	255°C
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-10 22:29:15

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TrimethylOrthoFormate(Tmof)

Trimethyl orthoformate

CAS: 149-73-5

Molecular Formula: C4H10O3

TrimethylOrthoFormate(Tmof) - Names and Identifiers

TrimethylOrthoFormate(Tmof) - Physico-chemical Properties

TrimethylOrthoFormate(Tmof) - Risk and Safety

TrimethylOrthoFormate(Tmof) - Nature

Open Data Verified Data

TrimethylOrthoFormate(Tmof) - Preparation Method

Open Data Verified Data

TrimethylOrthoFormate(Tmof) - Use

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TrimethylOrthoFormate(Tmof) - Safety

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TrimethylOrthoFormate(Tmof) - Reference Information

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TrimethylOrthoFormate(Tmof) Request for Quotation

Trimethyl orthoformate

CAS: 149-73-5

Molecular Formula: C4H10O3

TrimethylOrthoFormate(Tmof) - Names and Identifiers

TrimethylOrthoFormate(Tmof) - Physico-chemical Properties

TrimethylOrthoFormate(Tmof) - Risk and Safety

TrimethylOrthoFormate(Tmof) - Nature

Open Data Verified Data

TrimethylOrthoFormate(Tmof) - Preparation Method

Open Data Verified Data

TrimethylOrthoFormate(Tmof) - Use

Open Data Verified Data

TrimethylOrthoFormate(Tmof) - Safety

Open Data Verified Data

TrimethylOrthoFormate(Tmof) - Reference Information

Supplier List

TrimethylOrthoFormate(Tmof)