orthoformicacidmethylester
Trimethyl orthoformate
CAS: 149-73-5
Molecular Formula: C4H10O3
orthoformicacidmethylester - Names and Identifiers
| Name | Trimethyl orthoformate |
| Synonyms | Trimethoxymethane methoxymethanediol METHYLFORMIAT-ORTHO Methyl orthoformate Trimethylorthoformiat Trimethyl orthoformate Thrimethyl orthoformate Trimethyl ortho formate orthoformicacidmethylester TrimethylOrthoFormate(Tmof) Trimethyl Orthoformate(TMOF) Orthoformic acid trimethyl ester |
| CAS | 149-73-5 |
| EINECS | 205-745-7 |
| InChI | InChI:1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3 |
| InChIKey | PYOKUURKVVELLB-UHFFFAOYSA-N |
orthoformicacidmethylester - Physico-chemical Properties
| Molecular Formula | C4H10O3 |
| Molar Mass | 106.12 |
| Density | 0.97g/mLat 25°C(lit.) |
| Melting Point | -53 °C |
| Boling Point | 101-102°C(lit.) |
| Flash Point | 60°F |
| Water Solubility | 10 g/L (hydrolysis) |
| Solubility | Miscible with ether, alcohol and benzene. |
| Vapor Presure | 23.5 mm Hg ( 20 °C) |
| Vapor Density | 3.67 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless |
| Merck | 14,6884 |
| BRN | 969215 |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Explosive Limit | 1.4-44.6%(V) |
| Refractive Index | n20/D 1.379(lit.) |
| Physical and Chemical Properties | Colorless liquid. The boiling point is 103-105 ℃, the relative density is 0.967-971, the refractive index is 1.378, and the flash point is 15 ℃. Soluble in ethanol, ether, benzene, water decomposition. |
| Use | It is used as an intermediate for producing vitamin B1, sulfonamide drugs, antibiotics and other drugs. It is a raw material for spices and pesticides and an additive for polyurethane coatings. |
orthoformicacidmethylester - Risk and Safety
| Risk Codes | R11 - Highly Flammable R36 - Irritating to the eyes |
| Safety Description | S9 - Keep container in a well-ventilated place. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S29 - Do not empty into drains. |
| UN IDs | UN 3272 3/PG 2 |
| WGK Germany | 1 |
| RTECS | RM6650000 |
| TSCA | Yes |
| HS Code | 29159080 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 3130 mg/kg |
orthoformicacidmethylester - Nature
Open Data Verified Data
colorless liquid. The relative density is 0. 967~971, the boiling point is 103~105 ℃, the refractive index is 1.378, and the flash point is 15 ℃. Soluble in ethanol, ether, benzene.
Last Update：2024-01-02 23:10:35
orthoformicacidmethylester - Preparation Method
Open Data Verified Data
results from the reaction of chloroform and sodium methoxide.
Last Update：2022-01-01 10:33:49
orthoformicacidmethylester - Use
Open Data Verified Data
for the synthesis of vitamin B1, vitamin A, sulfadiazine and pipemidic acid pharmaceutical intermediates; Also used in the dye and perfume industry.
Last Update：2022-01-01 10:33:49
orthoformicacidmethylester - Safety
Open Data Verified Data
- This product is an irritant article. The oral LD50 of rats is 3130mg/kg, which has a stimulating effect on the skin, eyes and mucous membranes.
- This product is packed with 200kg galvanized steel drum or glass bottle external wooden box or calcium plastic box reinforcement liner. Store in a cool and ventilated warehouse, away from fire and open flame; Store and transport Isolation with oxidant to avoid sun exposure.
Last Update：2022-01-01 10:33:49
orthoformicacidmethylester - Reference Information
| LogP | -0.03-0.09 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | trimethyl orthoformate is used as a protecting group for aldehydes in organic synthesis and as an additive in polyurethane coatings, it is used as a dehydrating agent in the preparation of surface-modified colloidal silica nanoparticles. It is also used as a chemical intermediate for the preparation of vitamin B1 and sulfonamides. It can be used as an effective solvent for thallium (III) nitrate-mediated oxidation. |
| synthesis method | trimethyl orthoformate is prepared on an industrial scale by methanolysis of hydrogen cyanide: HCN 3 HOCH3 → HC(OCH3)3 NH3 trimethyl orthoformate can also be prepared from the reaction between chloroform and sodium methoxide. |
| Use | in the pharmaceutical industry for the production of vitamin B1, vitamin A, sulfadiazine, pipemidic acid and antibacterial agents, among them, the consumption of vitamin B1 accounted for the largest proportion of methyl formate. It is also used in the dye and fragrance industry. In the aspect of coating, it is used as a dehydrating agent to prevent hardening of polyurethane or epoxy coating due to hydration. It is used as an intermediate in the production of vitamin B1, sulfonamides, antibiotics and other drugs, and is a raw material for spices and pesticides and an additive for polyurethane coatings. Organic synthesis intermediates. Medicine is mainly used for the synthesis of vitamin B1, sulfonamides, antibiotics, etc.; Coating for the Prevention of polyurethane or epoxy coating due to hydration and hardening of the dehydrating agent; can also be used in the synthesis of perfume trimethyl orthoformate is an important intermediate in organic synthesis. Pesticides are mainly used in the synthesis of azoxystrobin, dimethyl ether and other pesticide intermediates. Medicine is mainly used for the synthesis of pipemidic acid, norfloxacin and other pharmaceutical intermediates. It is also widely used in coatings, dyes, spices and other industries. |
| production method | is obtained by the reaction of chloroform and methanol in the presence of caustic soda (or chloroform and sodium methoxide). |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | Reference range inhalation-rat LCL0: 4000 PPM/8 h |
| stimulation data | Skin-rabbits 500 mg/24 h mild; eye-rabbit 100 mg moderate |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| spontaneous combustion temperature | 255°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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