UBCS039

Name	UBCS039
Synonyms	UBCS039 4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-
CAS	358721-70-7

Molecular Formula	C16H13N3
Molar Mass	247.29
Density	1.25±0.1 g/cm3(Predicted)
Boling Point	453.9±45.0 °C(Predicted)
pKa	4.66±0.12(Predicted)
Storage Condition	2-8°C
Use	UBCS039 is the first synthetic, specific activator of SIRT6 that induces autophagy in human cancer cells with an EC50 value of 38 μm.
In vitro study	UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. UBCS039 leads to autophagosome accumulation in human cancer cells. UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation. Western Blot Analysis Cell Line: Human H1299 cells. Concentration: 75 μM. Incubation Time: 48 and 72 hours. Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. Western Blot Analysis Cell Line: Human H1299 cells. Concentration: 75 μM. Incubation Time: 48 and 72 hours. Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells. Cell Proliferation Assay Cell Line: Human H1299 cells. Concentration: 100 μM. Incubation Time: 48 and 72 hours. Result: Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.

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UBCS039