UBCS039 MedChemExpress (MCE)

Product Name	UBCS039
Synonyms	UBCS039;4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline;Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)-
CAS	358721-70-7
EINECS
Chemical Formula	C16H13N3
Molecular Weight	247.29
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Get quote
Descriptions	UBCS039 UBCS039 MedChemExpress (MCE) HY-115453 358721-70-7 99.06% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions UBCS039 UBCS039 MedChemExpress (MCE) HY-115453 358721-70-7 99.06% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells[2]. UBCS039 leads to autophagosome accumulation in human cancer cells[2]. UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation[2]. SIRT6 38 μM (EC50) \| \| \| \| \| \| \| \| \| \| [1]. Weijie You, et al. Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. 2017, 56, 1007-1011. [2]. Sara Iachettini, et al. Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells. Cell Death and Disease (2018) 9:996. [Content Brief]
Last Update	2025-04-01 14:45:47

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