berbamine
berbamine
CAS: 478-61-5
Molecular Formula: C37H40N2O6
berbamine - Names and Identifiers
| Name | berbamine |
| Synonyms | BERBAINE BERBAMINE berbamine Berbamine Dihydrochloride 6,6',7-trimethoxy-2,2'-dimethylberbaman-12-ol 6,6',7-trimethoxy-2,2'-dimethyl-berbaman-12-o 6,6',7-trimethoxy-2,2'-dimethylberbaman-12-ol BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL |
| CAS | 478-61-5 |
| EINECS | 207-523-5 |
| InChI | InChI=1/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1 |
berbamine - Physico-chemical Properties
| Molecular Formula | C37H40N2O6 |
| Molar Mass | 608.72 |
| Density | 1.1648 (rough estimate) |
| Melting Point | 198.5°C |
| Boling Point | 655.15°C (rough estimate) |
| Specific Rotation(α) | D20 +114.6° (c = 1.0 in chloroform) |
| Flash Point | 381.4°C |
| Solubility | Slightly soluble in water; soluble in ethanol, ether, chloroform and petroleum ether. |
| Vapor Presure | 1.19E-20mmHg at 25°C |
| Appearance | White crystal |
| pKa | pKa (20°): 7.33 in aq methanol |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD11501559 |
| Use | For the promotion of leukocyte proliferation drugs, for various causes of leukopenia |
berbamine - Reference
| Reference Show more | 1. Qingwang Liu, Junsong Wang, Lei Yang, Yuanwei Jia, Lingyi Kong,A rapid and sensitive LC–MS/MS assay for the determination of berbamine in rat plasma with application to preclinical pharmacokinetic study,Journal of Chromatography B,Volume 929,2013,Page 2. [IF=3.205] Qingwang Liu et al."A rapid and sensitive LC–MS/MS assay for the determination of berbamine in rat plasma with application to preclinical pharmacokinetic study."J Chromatogr B. 2013 Jun;929:70 |
berbamine - Reference Information
| Overview | Berbamine (Berbamine) is a bisbenzyl isoquinoline alkaloid found in Berberis plants. It is known that the medical effect of berbamine is mainly to increase white blood cells. It is used for leukopenia caused by various reasons. During radiotherapy and chemotherapy for cancer patients, it can also prevent leukopenia. |
| biological activity | Berbamine (BA, BBM) is a natural product of bisbenzyl isoquinoline isolated from Chinese herbal medicine yellow reed wood. It is a novel inhibitor of bcr/abl with potent anti-leukemia activity and an inhibitor of NF-κB. Berbamine (BA, BBM) inhibits the growth of cancer cells and induces apoptosis of human myeloma cells by targeting Ca²/calmodulin-dependent protein kinase II (CaMKII). |
| Target | Value |
| use | medicine to promote leukocyte hyperplasia, used for leukopenia caused by various reasons |
Last Update：2024-04-09 20:52:54
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CAS: 478-61-5
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