ert-Butyl4-hydroxy-2-oxopyrrolidine-1-carboxylate

ert-Butyl4-hydroxy-2-oxopyrrolidine-1-carboxylate - Names and Identifiers

Name	1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-oxo-, 1,1-dimethylethyl ester
Synonyms	1-Boc-4-hydroxy-2-oxo-pyrrolidine 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-oxo- ert-Butyl4-hydroxy-2-oxopyrrolidine-1-carboxylate TERT-BUTYL 4-HYDROXY-2-OXOPYRROLIDINE-1-CARBOXYLATE 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-oxo-, 1,1-dimethylethyl ester
CAS	409341-03-3

ert-Butyl4-hydroxy-2-oxopyrrolidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C9H15NO4
Molar Mass	201.22
Storage Condition	2-8°C

ert-Butyl4-hydroxy-2-oxopyrrolidine-1-carboxylate - Introduction

4-hydroxy-2-oxo-, 1,1-dimethyleyl ester (4-hydroxy-2-oxo-, 1-dimethyleyl ester) is an organic compound commonly referred to as N-Boc-Oxypyroglutamate. Its chemical formula is C12H19NO6.

The compound has the following properties:
-Appearance: Colorless solid
-Melting point: about 80-85°C
-Solubility: Soluble in some polar organic solvents, such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).

N-Boc-Oxypyroglutamate are mainly used in the field of organic synthesis, specific uses include:
-As a synthetic drug intermediate: The compound can be used to prepare various drugs, especially neuropeptide drugs.
-As an amino acid protecting group: The N-Boc(tert-butyloxycarbonyl) group can be used to protect the carboxyl group of the amino acid to avoid unnecessary reactions in organic synthesis.

The preparation method of N-Boc-Oxypyroglutamate usually involves the following steps:
1. 1-Pyrrolidinecarbonyl chloride (1-Pyrrolidinecarbonyl chloride) is obtained by reacting 1-pyrrolidine carboxylic acid (1-pyridinecarbonyl).
2. react 1-pyrrolidine chloride with 4-hydroxy -2-oxoproline in the presence of sodium carbonate to generate N-Boc-Oxypyroglutamate.

For safety information, please note the following:
-When handling this compound, take appropriate personal protective measures, such as wearing protective glasses, protective gloves and laboratory coats.
-Avoid inhaling the dust or vapor of the compound and ensure that it is operated under well-ventilated conditions.
-In case of ingestion or skin contact, seek medical help immediately and provide information about the compound to your doctor.

Last Update：2024-04-09 15:17:57