ketoconazole

ketoconazole - Names and Identifiers

Name	ketoconazole
Synonyms	Nsc317629 ketoconazole 1-[4-[4-[[2-(2 4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1 3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone 1-ACETYL-4-[4-[[2-(2, 4-DICHLOROPHENYL) -2-(1H- IMIDAZOL-1-YLMETHYL)-1, 3-DIOXOL cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1h-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine 1-[4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone 1-acetyl-4-(4-{[(2R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine 1-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone 1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone 1-[4-[4-[[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone 1-[4-(4-{[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
CAS	65277-42-1 79156-75-5
EINECS	265-667-4
InChI	InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23?,26-/m0/s1

ketoconazole - Physico-chemical Properties

Molecular Formula	C26H28Cl2N4O4
Molar Mass	531.43
Density	1.38
Melting Point	146℃
Boling Point	753.4±60.0 °C(Predicted)
Specific Rotation(α)	-10.5 ° (C=0.4, CHCl3)
Flash Point	409.4°C
Solubility	Insoluble in water
Vapor Presure	1.39E-22mmHg at 25°C
Appearance	White crystalline powder
pKa	6.88±0.12(Predicted)
Storage Condition	2-8℃
Sensitive	Sensitive to heat
Refractive Index	1.642
MDL	MFCD00058579
Physical and Chemical Properties	Melting Point: 146°C
Use	For antifungal drugs, used to treat beriberi and dandruff and other conditions

ketoconazole - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	R25 - Toxic if swallowed
Safety Description	S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811

ketoconazole - Upstream Downstream Industry

Raw Materials

p-Toluenesulfonamide
Diethanolamine
Triethylamine
Bromine

ketoconazole - Reference

Reference

1. Zhou Guojian, Ye Dongting, Deng Xuxing. Effects of yinhuang granule, Niuhuang Shangqing pill and Shuanghuanglian mixture on activity of drug metabolizing enzyme cyp3a_4 [J]. Asia-Pacific Traditional Medicine, 2016,12(15):19-22.
2. Zhou Guojian, Ye Dongting, Deng Xuxing. Effects of Huanglian Shangqing pills, Hugan Pian and Niuhuang Jiedu pills on activity of drug metabolizing enzyme CYP3A4 [J]. Chinese national and folk medicine, 2016, 10(v.25;No.279):22-24.
3. Zhou Guojian, Ye Dongting, Deng Xuxing. Effects of Banlangen granules, Yinzhihuang granules and compound berberine tablets on activity of drug metabolizing enzyme cyp3a_4 [J]. Chinese Medicine Review, 2017,23(03):72-74.
4. Zhong Jing, zuoxiaoting, Wang Xiaoqin, et al. Study on the induction of four active components of licorice [J]. Journal of Shihezi University: natural science edition, 2016, 34(004):468-472.
5. Peng Yan, Yang Chao, Jiang Yaozhang, etc. Isolation and identification of fine-pole Streptomyces from beef cattle [J]. Chinese Journal of Preventive Veterinary Medicine, 2020, v.42(01):86-89 99.
6. Ma Xiaoping, Yang Qiuxia, Yu cast, etc. Comparison of some biological characteristics and drug sensitivity test between wild strain (Z20) and mutant strain (Zt) of Cladosporium from giant panda [J]. Journal of Agricultural Sciences of Zhejiang, 2018(8):1328-1335.
7. Wang Chengyu, Li Dengke, Quan Zhengyang, Hu Ying also, Sun Zhenxiao. Study on hepatotoxicity and related components of Polygonum multiflorum based on cytochrome oxidase CYP2D6 [J]. Pharmacovigilance in China, 2021,18(03):220-227 239.
8. Chen Rui, Zhou Wei, Zhang Li, Zhu Gaogao, Huang Jing, Tang Lei. In vitro inhibition of five common Cytochrome P_(450) enzymes in human liver microsomes by bevacizumab acid A [J]. China Pharmacy, 2021,32(02):195-200.
9. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https://doi.org/10.1002/bdd.2214
10. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https://doi.org/10.1002/bdd.2214
11. [IF=4.411] Xu Zhang et al."In Vitro and In Situ Characterization of the Intestinal Absorption of Capilliposide B and Capilliposide C from Lysimachia capillipes Hemsl."Molecules. 2019 Jan;24(7):1227
12. [IF=5.076] Liu Zi-Jing et al."The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury."Oxid Med Cell Longev. 2019;2019:7283104
13. [IF=1.663] Wei Huang et al."Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo."Biopharm Drug Dispos. 2020 Feb;41(1-2):64-71
14. [IF=3.5] Ying-huan Hu et al."Inhibition of CYP3A4 enhances aloe-emodin induced hepatocyte injury."Toxicol In Vitro. 2021 Dec;:105276

ketoconazole - Nature

Open Data Verified Data

white crystalline powder. Melting Point 146 °c.

Last Update：2024-01-02 23:10:35

ketoconazole - Preparation Method

Open Data Verified Data

A mixture of 1-acetyl-4-(4-hydroxybenzene) piperazine, sodium cyanide, dimethyl sulfate and benzene was stirred at 40 °c for 1H, then 2-(2.4 monodichlorobenzene) was added -2-(1H-imidazole-1-ylmethyl)-1, 3-oxopentylcyclo-4-ylmethyl methanesulfonate, stirred at 100 ° C. For a certain time. The reaction product was post-treated to obtain ketoconazole.

Last Update：2022-01-01 09:08:35

ketoconazole - Use

Open Data Verified Data

imidazole antifungal drugs can inhibit the biosynthesis of ergosterol in fungal cell membrane, affect the permeability of cell membrane and inhibit its growth. Can be used for the treatment of superficial and deep mycosis, such as skin and onychomycosis, vaginal candidiasis, gastrointestinal fungal infections, etc., as well as by Candida albicans, Coccidioides, systemic infection caused by histoplasmosis.

Last Update：2022-01-01 09:08:36

ketoconazole - Safety

Open Data Verified Data

mouse, rat, guinea pig, dog LDso(mg/kg): 44, 86, 28, 49 intravenous injection; 702, 227, 202, 780 oral.

Last Update：2022-01-01 09:08:37

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Product Name: Ketoconazole Request for quotation
CAS: 65277-42-1
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589

Wechat: +86 19849939632

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: ketoconazole Request for quotation
CAS: 65277-42-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple SpecificationsSpot supply

Product Name: Ketoconazole Visit Supplier Webpage Request for quotation
CAS: 65277-42-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

ketoconazole

Raw Materials for ketoconazole

p-Toluenesulfonamide
Diethanolamine
Triethylamine
Bromine

ketoconazole

ketoconazole

CAS: 65277-42-1;79156-75-5

Molecular Formula: C26H28Cl2N4O4

ketoconazole - Names and Identifiers

ketoconazole - Physico-chemical Properties

ketoconazole - Risk and Safety

ketoconazole - Upstream Downstream Industry

ketoconazole - Reference

ketoconazole - Nature

Open Data Verified Data

ketoconazole - Preparation Method

Open Data Verified Data

ketoconazole - Use

Open Data Verified Data

ketoconazole - Safety

Open Data Verified Data

Supplier List

ketoconazole Request for Quotation

ketoconazole

CAS: 65277-42-1;79156-75-5

Molecular Formula: C26H28Cl2N4O4

ketoconazole - Names and Identifiers

ketoconazole - Physico-chemical Properties

ketoconazole - Risk and Safety

ketoconazole - Upstream Downstream Industry

ketoconazole - Reference

ketoconazole - Nature

Open Data Verified Data

ketoconazole - Preparation Method

Open Data Verified Data

ketoconazole - Use

Open Data Verified Data

ketoconazole - Safety

Open Data Verified Data

Supplier List

ketoconazole