Name | osalmid |
Synonyms | LOIRD auxobil OSALMID osalmid Oksafenamide N-Salicoylaminophenol 4-Hydroxysalicylanilide 4'-hydroxysalicylanilide 4'-hydroxy-salicylanilid 2-Hydroxy-N-(4-hydroxyphenyl)benzamide 2-hydroxy-n-(4-hydroxyphenyl)-benzamid 2-hydroxy-n-(4-hydroxyphenyl)-benzamide 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide 2-Hydroxy-N-(4-Hydroxyphenyl)-Benzamide benzamide, 2-hydroxy-N-(4-hydroxyphenyl)- |
CAS | 526-18-1 |
EINECS | 208-385-9 |
InChI | InChI=1/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17) |
Molecular Formula | C13H11NO3 |
Molar Mass | 229.23 |
Density | 1.2084 (rough estimate) |
Melting Point | 179° |
Boling Point | 371.13°C (rough estimate) |
Flash Point | 165.9°C |
Vapor Presure | 2.12E-05mmHg at 25°C |
Appearance | White crystal |
pKa | 8.40±0.30(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.5500 (estimate) |
Physical and Chemical Properties | White crystal, odorless. Melting point 179 ℃. Soluble in methanol, ethanol, acetone, ether, slightly soluble in hot water, benzene, toluene, insoluble in water and acetic acid. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
Toxicity | LD50 oral in rat: 6702mg/kg |
overview | salparacetamol is a phenolic derivative. this product is a choleretic drug, which can promote bile secretion and has a similar effect to dehydrocholic acid. It is clinically applicable to cholecystitis, biliary tract inflammation, cholelithiasis and gallbladder postoperative syndrome. |
mechanism of action | licholinol can inhibit the synthesis of prostaglandins in the central nervous system and hypothalamus, and has antipyretic and external analgesic effects; It can enhance the excitement process of the cerebral cortex, invigorate the spirit, and can be used in conjunction with antipyretic analgesics to strengthen its antipyretic and analgesic effect; it works by directly stimulating α-adrenergic receptors, rarely causing central nervous system excitement, but it has the effect of selectively contracting the capillaries of the upper respiratory tract, eliminating nasopharyngeal mucosal congestion, and reducing nasal congestion symptoms; it can resist the microvascular caused by histamine Expansion and increased capillary permeability reduce allergic symptoms such as tearing, sneezing, and runny nose; promote carbohydrate metabolism and maintain the normal function of the heart, nerve and digestive system. |
chemical properties | white crystal, odorless. Melting point 179 ℃. Soluble in methanol, ethanol, acetone, ether, slightly soluble in hot water, benzene, toluene, insoluble in water and acetic acid. |
use | this product is a choleretic drug. for cholecystitis, biliary tract inflammation, cholelithiasis and biliary tract postoperative syndrome for the treatment of acute and chronic cholecystitis and gallstone removal, and at the same time has the effect of removing yellowish bile |
production method | obtained by the reaction of phenyl salicylate and p-aminophenol. |
EPA chemical information | information provided by: ofmpub.epa.gov (external link) |