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p-Bromoacetophenone

4'-Bromoacetophenone

CAS: 99-90-1

Molecular Formula: C8H7BrO

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p-Bromoacetophenone - Names and Identifiers

Name 4'-Bromoacetophenone
Synonyms 4'-Bromoacetophene
4-Bromoacetophenone
p-Bromoacetophenone
p-Bromo acetophenone
4'-Bromoacetophenone
1-Acetyl-4-bromobenzene
1-(4-Bromophenyl)ethanone
CAS 99-90-1
EINECS 202-799-3
InChI InChI=1/C8H7BrO/c1-6(10)7-2-4-8(9)5-3-7/h2-5H,1H3

p-Bromoacetophenone - Physico-chemical Properties

Molecular FormulaC8H7BrO
Molar Mass199.04
Density1.64
Melting Point48-52℃
Boling Point255℃
Flash Point>230 °F
Water SolubilitySoluble in Chloroform. Insoluble in water.
AppearanceWhite crystal
Storage ConditionRoom Temprature
Refractive Index1.5540 (estimate)
MDLMFCD00000105
Physical and Chemical PropertiesDensity 1.64
melting point 48-52°C
boiling point 255°C
UseUsed as a pharmaceutical Intermediate

p-Bromoacetophenone - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR36/38 - Irritating to eyes and skin.
Safety DescriptionS22 - Do not breathe dust.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDsUN 3261 8/PG 2

p-Bromoacetophenone - Upstream Downstream Industry

Raw MaterialsBromobenzene
Aluminium chloride hexahydrate
Downstream ProductsETHYL 4-ACETYLBENZOATE
5-(4-BROMO-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE
ETHYL 2-AMINO-4-(4-BROMOPHENYL)-3-THIOPHENECARBOXYLATE
1,3,5-Tris(4-bromophenyl)benzene
4-(4-BROMOPHENYL)-1,2,3-THIADIAZOLE
4-Acetylphenylboronic acid
4-Acetyl-2-fluorobiphenyl
1-(2-NITRO-BIPHENYL-4-YL)-ETHANONE
4-Bromophenethyl alcohol
1,3,5-Tris(p-formylphenyl)benzene
1,4-DIACETYLBENZENE
1-(2-amino[1,1'-biphenyl]-4-yl)ethan-1-one
2-(4-BROMO-PHENYL)-1H-INDOLE
2,4'-Dibromoacetophenone
4-Bromomandelic acid
1-(4-Bromophenyl)ethylamine hydrochloride
4-ACETYLBENZALDEHYDE

p-Bromoacetophenone - Introduction

Soluble in ethanol, ether, glacial acetic acid, benzene, carbon disulfide and petroleum ether, insoluble in water. Easy to volatilize with water vapor.
Last Update：2022-10-16 17:30:32

p-Bromoacetophenone - Use

use

  1. p-bromoacetophenone is an important organic synthesis intermediate, which is widely used in the synthesis of medicines, pesticides, dyes, flavors, fragrances, perfumes, etc.
  2. Intermediates in organic synthesis. Used in dyes, medicines and reagents.
  3. for dye organic synthesis
  4. Used as a pharmaceutical intermediate

Preparation

At present, the preparation methods of p-bromoacetophenone mainly include Friedel-Crafts acylation method, 1-(4-bromophenyl) ethanol oxidation method and p-bromoethylbenzene oxidation method, etc. Among them, p-bromoethylbenzene oxidation method is divided into chemical oxidation method and molecular oxygen oxidation method. As an oxidant with low price, clean and pollution-free and good atomic economy, the method of preparing p-bro.

chemical properties

Color flake crystals. Melting point 51 ℃, boiling point 255.5 ℃(97.9kPa),130 ℃(1.46kPa),117 ℃(0.93kPa). Soluble in ethanol, ether, glacial acetic acid, benzene, carbon disulfide and petroleum ether, insoluble in water. Easy to volatilize with water vapor.

production method

Bromobenzene and acetic anhydride are obtained by reacting in the presence of aluminum trichloride. Add bromobenzene and dry carbon disulfide into the reactor, put into powdered anhydrous aluminum trichloride, heat until reflux starts, stop heating, add acetic anhydride dropwise, reflux for 1h after adding, evaporate carbon disulfide, pour the reactant into the mixture of hydrochloric acid and ice water while hot, filter dry, and distill under reduced pressure to obtain the finished product.

Last Update：2024-04-09 21:01:54

p-Bromoacetophenone - Nature

Melting point 108-110°C(lit.)

boiling point 255 c (lit.)

density 1.64

refractive index 1.5540 (estimate)

flash point> 230 f

storage conditions Store below 30 c.

solubility methanol: 0.1 g/mL, clear

morphological Crystals or Crystalline Flakes

color white to light yellow

water solubility Soluble in Chloroform. Insoluble in water.

Merck 14,1403

BRN 386015

InChIKey WYECURVXVYPVAT-UHFFFAOYSA-N

NIST chemical information

Ethanone, 1-(4-bromophenyl)-(99-90-1)

EPA chemical information

Ethanone, 1-(4-bromophenyl)- (99-90-1)
Last Update：2024-04-09 18:58:34
p-Bromoacetophenone
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Nantong Reform Petro-Chemical CO., LTD.
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Product Name: 4'-Bromoacetophenone Request for quotation
CAS: 99-90-1
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Mefenamic Acid Impurity 34 Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 4'-Bromoacetophenone Request for quotation
CAS: 99-90-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 4'-Bromoacetophenone Request for quotation
CAS: 99-90-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
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Spot supply
Product Name: 4'-Bromoacetophenone Visit Supplier Webpage Request for quotation
CAS: 99-90-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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Wechat: 18301782025
邹平铭远进出口贸易有限公司
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CAS: 99-90-1
Tel: 15954734980
Email: 343896208@qq.com
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View History
p-Bromoacetophenone
Raw Materials for p-Bromoacetophenone
Bromobenzene
Aluminium chloride hexahydrate
Downstream Products for p-Bromoacetophenone
ETHYL 4-ACETYLBENZOATE
ETHYL 2-AMINO-4-(4-BROMOPHENYL)-3-THIOPHENECARBOXYLATE
1,3,5-Tris(4-bromophenyl)benzene
4-(4-BROMOPHENYL)-1,2,3-THIADIAZOLE
4-Acetyl-2-fluorobiphenyl
1-(2-NITRO-BIPHENYL-4-YL)-ETHANONE
1,3,5-Tris(p-formylphenyl)benzene
1,4-DIACETYLBENZENE
1-(2-amino[1,1'-biphenyl]-4-yl)ethan-1-one
2-(4-BROMO-PHENYL)-1H-INDOLE
1-(4-Bromophenyl)ethylamine hydrochloride
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