propagin
Propyl 4-hydroxybenzoate
CAS: 94-13-3
Molecular Formula: C10H12O3
propagin - Names and Identifiers
propagin - Physico-chemical Properties
| Molecular Formula | C10H12O3 |
| Molar Mass | 180.2 |
| Density | 1.134g/cm3 |
| Melting Point | 95-99℃ |
| Boling Point | 294.3°C at 760 mmHg |
| Flash Point | 124.6°C |
| Water Solubility | <0.1 g/100 mL at 12℃ |
| Solubility | Soluble in ethanol, ether, acetone and other organic solvents, slightly soluble in water. |
| Vapor Presure | 0.00093mmHg at 25°C |
| Appearance | White crystalline powder |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.531 |
| MDL | MFCD00002354 |
| Physical and Chemical Properties | Character: white crystal, with special odor. Propyl p-carboxybenzoate is colorless fine crystal or white crystalline powder, almost odorless, slightly astringent soluble in ethanol, ether, acetone and other organic solvents, slightly soluble in water. |
| Use | As a bacteriostatic preservative in pharmaceuticals, cosmetics |
propagin - Risk and Safety
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
propagin - Nature
Open Data Verified Data
colorless fine crystal or white crystalline powder, almost odorless, slightly astringent. The melting point was 95-98 °c. Soluble in 2000 water, soluble in ethanol (95g/lOOmL), propylene glycol (26g/lOOmL) and acetone (105g/lOOmL) and other organic solvents.
Last Update：2024-01-02 23:10:35
propagin - Preparation Method
Open Data Verified Data
from p-Hydroxybenzoic acid and N-propanol esterification, decolorization, recrystallization.
Last Update：2022-01-01 10:09:57
propagin - Standard
Authoritative Data Verified Data
This product is propyl 4-hydroxybenzoate. Calculated as dry product, including C1()H1203 should be 98.0% ~ 102.0%.
Last Update：2024-01-02 23:10:35
propagin - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder.
- This product is soluble in methanol, ethanol or ether, slightly soluble in hot water, almost insoluble in water.
melting point
The melting point of this product (General 0612) is 96 ~ 99C.
Last Update：2022-01-01 11:25:40
propagin - Use
Open Data Verified Data
preservative. See ethyl paraben for others.
Last Update：2022-01-01 10:09:58
propagin - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take this product, dissolve and dilute with ethanol to make a solution containing about 5mg per 1 ml, and measure by UV-Vis spectrophotometry (General rule 0401), there is an absorption maximum at a wavelength of 258mn.
- The infrared absorption spectrum of this product should be consistent with the control spectrum (Spectrum set 852).
Last Update：2022-01-01 11:25:41
propagin - Exam
Authoritative Data Verified Data
acidity
Take 2ml of solution under the items of clarity and color, add 2M l of ethanol and 5ml of water, shake well, add 2 drops of bromocresol green indicator solution, and use sodium hydroxide titration solution (0. lm o l/L) titration to blue, consumption of sodium hydroxide titration solution (0. lm o l/L) must not pass 0. lm l.
clarity and color of solution
take this product l.O g, after dissolving with 0901 of ethanol, check according to law (general rule and General Rule 0 9 0 2 ) , the solution should be clear and colorless, it shall not be deeper than the yellow or yellow-green standard colorimetric solution No. 1 (General rule 0901 method 1).
chloride
take this product 2 .0g, add 50ml of water, 80X: water bath heating for 5 minutes, let cool, filter, take filtrate 5 .0M l, checked by law (General rule 0801), must not be more concentrated (0.035%) than the control solution made of standard sodium chloride solution.
salt
take 25ml of filtrate under chloride item, check according to law (General Rule 0 8 0 2 ) , and standard potassium sulfate solution 2. Compared with the control solution made of 4m l, it should not be more concentrated (0. 024%).
Related substances
take this product, add the mobile phase to dissolve and dilute the solution containing lm g per lm l as the test solution; Take lm l with precision and put it in a 100ml measuring flask, the mobile phase was diluted to the scale, and the solution was used as a control solution. According to the chromatographic conditions under the content determination item, take 20M1 of the control solution and inject it into the human liquid chromatograph to adjust the detection sensitivity so that the peak height of the main component peak is about 25% of the full scale, then 20ul of the test solution and the control solution are accurately measured, and the human liquid chromatograph is injected respectively, and the chromatogram is recorded to 4 times of the retention time of the main peak. If the impurity peak is shown in the chromatogram of the test solution, the area of the single impurity peak shall not be greater than 0 of the area of the main peak of the control solution. 4 times (0 .4% ), the sum of each impurity peak area shall not be greater than 0. 8 times (0. 8%).
loss on drying
take this product, put it in a silica gel dryer, and dry it under reduced pressure to constant weight. The weight loss shall not exceed 0831 (general rule).
ignition residue
The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
The residue left under the ignition residue item shall not contain more than 20 parts per million of heavy metals as determined by law (general chapter 0821 second method).
arsenic salt
take this product l.0g, add calcium hydroxide l.O g, mix, add a small amount of water, stir evenly, dry, first burn with small fire to charring, then burn at 500 ~ 600TC to completely Ash, cool, add hydrochloric acid (5m) and water (23ml), check according to law (General Principles 0822 The first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 11:25:42
propagin - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler; Methanol -1% glacial acetic acid (60 : 40) as mobile phase, the detection wavelength was 254nm. Weigh the appropriate amount of methyl hydroxybenzoate and ethyl hydroxybenzoate, add the mobile phase to dissolve and dilute to make the L01-containing solution in each lml. Inject 20ul into human liquid chromatograph and record the chromatogram, the degree of separation between the methyl paraben peak and the ethyl paraben peak should meet the requirements.
- The determination method is to take an appropriate amount of this product, precisely weigh it, add mobile phase to dissolve and quantitatively dilute it to make hydroxyphenyl propyl ester 0 per lm I. lm g solution, the precise amount of 20M1 injection of human liquid chromatography, record the chromatogram; Another appropriate amount of hydroxyphenyl propyl ester reference substance, the same method for determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:25:42
propagin - Category
Authoritative Data Verified Data
pharmaceutical excipients, bacteriostatic agents.
Last Update：2022-01-01 11:25:42
propagin - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:25:42
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Product Name: Propyl 4-hydroxybenzoate Request for quotationCAS: 94-13-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Propyl 4-hydroxybenzoate Request for quotationCAS: 94-13-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Methylparaben Impurity 2（Propylparaben） Visit Supplier Webpage Request for quotationCAS: 94-13-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: Propyl 4-hydroxybenzoate/Propylparaben Request for quotationCAS: 94-13-3
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: Propyl 4-hydroxybenzoate Request for quotation
CAS: 94-13-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 94-13-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Propyl paraben Visit Supplier Webpage Request for quotationCAS: 94-13-3
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Email: 3008007409@qq.com
Mobile: 18021002903
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