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threo-Dopaserine

droxidopa

CAS: 23651-95-8

Molecular Formula: C9H11NO5

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threo-Dopaserine - Names and Identifiers

Name droxidopa
Synonyms SM 5688
droxidopa
Droxidopa (JAN)
threo-Dopaserine
beta,3-Dihydroxytyrosine
tyrosine, beta,3-dihydroxy-
Serine, 3-(3,4-dihydroxyphenyl)-
L-threo-3,4-Dihydroxyphenylserine
L-Tyrosine, β,3-dihydroxy-, (βR)-
L-Tyrosine, b,3-dihydroxy-, threo-
(betaS)-beta,3-dihydroxy-D-tyrosine
L-threo-b-(3,4-Dihydroxyphenyl)serine
Serine, 3-(3,4-dihydroxyphenyl)-, L-threo- (8CI)
threo-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid
(2S,3S)-2-ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate
CAS 23651-95-8
InChI InChI=1/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8-/m0/s1

threo-Dopaserine - Physico-chemical Properties

Molecular FormulaC9H11NO5
Molar Mass213.19
Density1.608±0.06 g/cm3(Predicted)
Melting Point232-235° (dec); mp 229-232° (dec) (Ohashi)
Boling Point549.8±50.0 °C(Predicted)
Specific Rotation(α)D20 -39° (c = 1 in 1N aq HCl); D20 -42.0° (c = 1 in 1N aq HCl)
Flash Point286.3°C
Solubility DMSO <1 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Vapor Presure6.39E-13mmHg at 25°C
Appearancepowder
Colorwhite to tan
Merck14,3457
pKa2.09±0.24(Predicted)
Storage Condition-20°C
StabilityHygroscopic
Refractive Index1.692
MDLMFCD00799030
Physical and Chemical PropertiesCrystallization from ethanol and diethyl ether, melting point 232-235 °c (decomposition). [Α] D20-39 °(C = 1, 1 mol/L hydrochloric acid). There are also crystals from water and L-ascorbic acid, melting point 229~232 °c (decomposition). [Α] D20-42.0 °(C = 1,1mol/L hydrochloric acid). White to light brown crystalline or crystalline powder, odorless and tasteless. Soluble in dilute hydrochloric acid, insoluble in water, a few insoluble in methanol, ethanol, acetic acid, acetone, chloroform or ether. Acute toxicity LD50 rats and mice (rng/kg):>10000 P. O. Acute toxicity LD50 dog and Rhesus (mg/kg):>5000 Oral.
In vitro studyDroxidopa is a pro-drug with a similar structure to norepinephrine and contains a carboxyl group. Droxidopa is different from Norepinephrine. It can be taken orally and converted into norepinephrine under the action of DOPA decarboxylase after absorption, so it can increase the content of neurotransmitters. The converted norepinephrine is the same as that in the body. Droxidopa is well tolerated. Droxidopa can act to raise blood pressure in three different ways: a) as a central stimulator of sympathetic activity B) as a peripheral sympathetic neurotransmitter c) as a circulating hormone. Droxidopa alone can increase upright blood pressure. Droxidopa also crosses the blood-brain barrier and is converted to norepinephrine and epinephrine in the brain
In vivo studyAcute administration of droxidopa in PVL and BDL rats resulted in a significant and sustained increase in arterial blood pressure and mesenteric arterial vascular resistance, and a significant decrease in mesenteric arterial and portal blood flow, without affecting portal pressure and renal blood flow. The ratios of p-eNOS/eNOS and p-AKT/AKT decreased and RhoK activity increased in SMA in Droxidopa-treated rats.

threo-Dopaserine - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSVT9626010
HS Code29225090

threo-Dopaserine - Preparation solution concentration reference

 1mg5mg10mg
1 mM4.691 ml23.453 ml46.907 ml
5 mM0.938 ml4.691 ml9.381 ml
10 mM0.469 ml2.345 ml4.691 ml
5 mM0.094 ml0.469 ml0.938 ml
Last Update：2024-01-02 23:10:35
threo-Dopaserine
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
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CAS: 23651-95-8
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Zouping Mingxing Chemical Co., Ltd.
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CAS: 23651-95-8
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Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Droxidopa Visit Supplier Webpage Request for quotation
CAS: 23651-95-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: droxidopa Request for quotation
CAS: 23651-95-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Droxidopa Visit Supplier Webpage Request for quotation
CAS: 23651-95-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Zouping Mingxing Chemical Co., Ltd.
Product Name: droxidopa Request for quotation
CAS: 23651-95-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
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threo-Dopaserine
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