β-苯乙胺
Phenethylamine
CAS: 64-04-0
Molecular Formula: C8H11N
β-苯乙胺 - Names and Identifiers
| Name | Phenethylamine |
| Synonyms | beta-Phenyl Phenethylamine 2-Phenylethylamine β-phenylethylamine PHENETHYLAMINE, STANDARD FOR GC 2-Phenylethylamine,ScintillationGrade |
| CAS | 64-04-0 |
| EINECS | 200-574-4 |
| InChI | InChI=1/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2 |
| InChIKey | BHHGXPLMPWCGHP-UHFFFAOYSA-N |
β-苯乙胺 - Physico-chemical Properties
| Molecular Formula | C8H11N |
| Molar Mass | 121.18 |
| Density | 0.962 g/mL at 20 °C (lit.) |
| Melting Point | -60 °C |
| Boling Point | 197-200 °C (lit.) |
| Flash Point | 195°F |
| JECFA Number | 1589 |
| Water Solubility | SOLUBLE |
| Solubility | alcohol: freely soluble(lit.) |
| Vapor Presure | 0.4 hPa (20 °C) |
| Vapor Density | 4.18 (vs air) |
| Appearance | liquid |
| Color | clear, colorless |
| Odor | fishy odor |
| Merck | 14,6026 |
| BRN | 507488 |
| pKa | 9.84(at 25℃) |
| PH | 11.5 (4.3g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. |
| Sensitive | Air Sensitive |
| Explosive Limit | 1.0-5.5%(V) |
| Refractive Index | n20/D 1.533(lit.) |
| Physical and Chemical Properties | Density 0.962 melting point -60°C boiling point 194-202°C refractive index 1.532-1.534 flash point 90°C water-SOLUBLE solution |
| Use | Pharmaceutical intermediates of jiangtangling, also used in other organic synthesis |
| In vitro study | 2-Phenylethanamine (PEA) is soluble in water, ethanol, and ether. Phenethylamine is a skin irritant and possible sensitizer. 2-Phenylethanamine is believed to function as a neuromodulator or neurotransmitter (a trace amine). It is also found in many foods such as chocolate, especially after microbial fermentation. 2-Phenylethanamine is a precursor to the neurotransmitter phenylethanolamine. High levels of 2-Phenylethanamine have been found in the urine of schizophrenics but it is not significantly elevated in the serum or CSF of schizophrenics. Urinary levels of 2-Phenylethanamine are significantly lower in children with attention deficit hyperactivity disorder. 2-Phenylethanamine is useful for scaring off rodent pests. |
β-苯乙胺 - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2922 8/PG 2 |
| WGK Germany | 1 |
| RTECS | SG8750000 |
| FLUKA BRAND F CODES | 9-23 |
| TSCA | Yes |
| HS Code | 29214980 |
| Hazard Class | 8 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 300 mg/kg |
β-苯乙胺 - Upstream Downstream Industry
| Downstream Products | Glipizide |
β-苯乙胺 - Reference Information
| FEMA | 3220 | PHENETHYLAMINE |
| pH range of acid-base indicator discoloration | 11.5 at 4.3g/l at 20°C |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | 2-phenomylethanamine is considered to be a neuromodulator or neurotransmitter. |
| purpose | This product is an intermediate of jiangtangling. Also used in other organic synthesis. is an intermediate of the drug jiangtangling, also used in other organic synthesis organic synthesis. Scintillation counters are used as carbon dioxide absorbers. |
| production method | is obtained by pressure catalytic hydrogenation of phenylacetonitrile. The liquid ammonia was introduced into phenylacetonitrile, cooled and absorbed, mixed with Raney nickel, and added into the autoclave to remove air and vent hydrogen. Reaction is carried out at 80-120 ° C. For 3H at about 10MPa until hydrogen is no longer absorbed. The reaction is cooled to depressurize and filtered. The filtrate was distilled under reduced pressure to collect a 90-93 ° C. (2kPa) fraction, I .e., 2-phenylethylamine. The yield was 90%. If 2-phenylethylamine hydrochloride (156-28-5) is prepared, the above filtrate is taken, adjusted to pH 3-4 with hydrochloric acid below 60 ° C., cooled to 5 ° C., allowed to stand for 8 hours and filtered. The hydrochloride is a plate-like crystal. Melting point 223-224 C (217 C). |
| spontaneous combustion temperature | 425°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:54:55
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