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利马前列素(干冰运输)

(2E)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid (non-preferred name)

CAS: 74397-12-9;114868-74-5;114868-76-7;85679-52-3

Molecular Formula: C22H36O5

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利马前列素(干冰运输) - Names and Identifiers

Name (2E)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid (non-preferred name)
Synonyms OP1206
ONO 1206
Limaprost
,13e,15s,17s)-
17S,20-Dimethyl-trans-D2-PGE1
17S-Methyl-w-homo-trans-D2-PGE1
11α,15s-dihydroxy-17s,20-dimethyl-9-oxo-prosta-2e,13e-dien-1-oic acid
9-Oxo-11a,15a-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic Acid
(2e,11-alpha,13e,15s,17s)-11,15-dihydroxy-17,20-dimethyl-9-oxoprost-2,13-die
2E,11a,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic Acid
Prosta-2,13-dien-1-oic acid,11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-
Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-
17α,20-dimethyl-δ2-PGE1, 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
(E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)-2-heptenoic acid
(2E)-7-[(1R)-2β-[(1E,3S,5S)-3-Hydroxy-5-methyl-1-nonenyl]-3α-hydroxy-5-oxocyclopentan-1α-yl]-2-heptenoic acid
2-Heptenoicacid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-,(2E)-
(2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic acid
2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)- (9CI)
(2E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl}-2-heptenoic acid (non-preferred name)
(2E)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid (non-preferred name)
(E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)-2-heptenoic acid 17S-Methyl-w-homo-trans-D2-PGE1
CAS 74397-12-9
114868-74-5
114868-76-7
85679-52-3
InChI InChI=1/C22H36O5/c1-3-4-9-16(2)14-17(23)12-13-19-18(20(24)15-21(19)25)10-7-5-6-8-11-22(26)27/h8,11-13,16-19,21,23,25H,3-7,9-10,14-15H2,1-2H3,(H,26,27)/b11-8+,13-12+/t16-,17+,18+,19+,21+/m0/s1

利马前列素(干冰运输) - Physico-chemical Properties

Molecular FormulaC22H36O5
Molar Mass380.52
Density1.118
Melting Point97-100°
Boling Point550.6±50.0 °C(Predicted)
Flash Point300.9°C
Solubility DMF: soluble
Vapor Presure2.03E-14mmHg at 25°C
Appearancecrystalline
pKa4.78±0.10(Predicted)
Storage Condition-20°C
Refractive Index1.55
Physical and Chemical PropertiesWhite Crystal, melting point 97~100 deg C.
In vitro study Limaprost inhibits the IL-1-mediated induction of nerve growth factor (NGF) in a concentration-dependent manner with an IC 50 value of 70.9  nM human IVD cells.
In vivo study Limaprost (OP1206) given orally at more than 100 mg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG). Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential. Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg). Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG.

利马前列素(干冰运输) - Risk and Safety

Hazard SymbolsT - Toxic
Toxic
Risk Codes25 - Toxic if swallowed
Safety DescriptionS36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDsUN 2811 6.1/PG 2
WGK Germany3
RTECSUK8362500
利马前列素(干冰运输)
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MedChemExpress (MCE)
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Product Name: 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206 Visit Supplier Webpage Request for quotation
CAS: 74397-12-9
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SKYRUN INDUSTRIAL CO.,LTD
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Product Name: LIMAPROST Visit Supplier Webpage Request for quotation
CAS: 74397-12-9
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Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Limaprost Visit Supplier Webpage Request for quotation
CAS: 74397-12-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: Limaprost Visit Supplier Webpage Request for quotation
CAS: 74397-12-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Limaprost Visit Supplier Webpage Request for quotation
CAS: 74397-12-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Taizhou Crene Biotechnology Co., Ltd.
Product Name: Limaprost Request for quotation
CAS: 74397-12-9
Tel: 0576-88813233
Email: sales@crene.cn
Mobile: 13396922869
QQ: 9246768 Click to send a QQ messageSend QQ message
View History
利马前列素(干冰运输)
5-(2-氨基丙基)-1-[3-(苯甲酰氧基)丙基]-2,3-二氢-1H-吲哚-7-甲腈
2-芳基-1,3-二氢苯并咪唑
1-(3,4-二氯苯基)-1-丙酮
Reactive Orange 2R
双环[2.2.1]庚烷-2,3-二醇
Anglislite
3-((6-溴吡啶-2-基)氨基)丙酸
Co-Formula CFS-290
Emtmpc
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