嘧啶(阴凉)
Pyrimidine
CAS: 289-95-2;25247-63-6
Molecular Formula: C4H4N2
嘧啶(阴凉) - Names and Identifiers
| Name | Pyrimidine |
| Synonyms | Miazine m-Diazine NSC 89305 Pyrimidine 1,3-Diazine Metadiazine 1,3-Diazabenzene |
| CAS | 289-95-2 25247-63-6 |
| EINECS | 206-026-0 |
| InChI | InChI=1/C4H4N2/c1-2-5-4-6-3-1/h1-4H |
嘧啶(阴凉) - Physico-chemical Properties
| Molecular Formula | C4H4N2 |
| Molar Mass | 80.09 |
| Density | 1.055g/cm3 |
| Melting Point | 20-22℃ |
| Boling Point | 122.4°C at 760 mmHg |
| Flash Point | 31.1°C |
| Water Solubility | soluble |
| Vapor Presure | 16.8mmHg at 25°C |
| Appearance | Form Liquid, color Clear colorless to orange |
| pKa | 1.23(at 20℃) |
| Storage Condition | Flammables area |
| Stability | Stable, but air-sensitive and hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Flammable. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.503 |
| MDL | MFCD00006059 |
| Physical and Chemical Properties | Melting Point: 19-22°C Boiling Point: 123-124°C density: 1.016g/mL at 25°C |
| Use | Used as raw materials for pharmaceutical intermediates, photosensitizers, etc |
嘧啶(阴凉) - Risk and Safety
| Risk Codes | R10 - Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 1993 |
| WGK Germany | 3 |
| RTECS | UV6263000 |
| TSCA | Yes |
| HS Code | 29335990 |
| Hazard Class | 3 |
| Packing Group | III |
嘧啶(阴凉) - Upstream Downstream Industry
| Raw Materials | P-XYLENE-D10 |
| Downstream Products | 4-Aminopyrimidine PYRIMIDIN-4-YL-METHANOL |
嘧啶(阴凉) - Introduction
Soluble in water, ethanol and ether
Last Update：2022-10-16 17:24:17
嘧啶(阴凉) - Nature
| solubility | soluble |
| sensitivity | Hygroscopic |
| Merck | 14,7987 |
| BRN | 103894 |
| NIST chemical information | 1,3-Diazine(289-95-2) |
| EPA chemical information | Pyrimidine (289-95-2) |
Last Update：2024-04-09 01:59:50
嘧啶(阴凉) - Uses and synthesis methods
pyrimidine base
One of the chemical components of pyrimidine base nucleotides is composed of carbon, nitrogen, hydrogen, oxygen and other elements. Pyrimidine bases include uracil, cytosine and thymine, where uracil and cytosine constitute the bases in the ribonucleic acid molecule, and thymine and cytosine constitute the bases in the deoxyribonucleic acid molecule. Pyrimidine base has strong absorption effect on ultraviolet light wave with wavelength of 250 ~ 280nm. The raw materials for its synthesis are derived from carbamoyl phosphate and aspartic acid. Pyrimidine base can also be metabolized and decomposed into carbon dioxide, β alanine and β aminoisobutyric acid. Some patients due to congenital factors or taking certain drugs, can cause pyrimidine metabolism disorders, causing whorky aciduria.
fluorouracil
Fluorouracil is a pyrimidine antimetabolite. In vivo, it is first converted to 5-fluoro-2-deoxyuracil nucleotide (FUdRP), inhibits deoxythymidylate synthase (TMPS), prevents deoxyuracil nucleotide from being converted into thymine nucleotide, and interferes with DNA synthesis, leading to cell damage and death. The effect is stronger in the presence of aldehyde hydrofolate (CF), because FUdRP, FH4 and TMPS can form a triple complex, which makes the active metabolite of the drug more tightly bound to the enzyme, so the effect of adding CF when using fluorouracil is better, especially when used in colorectal cancer. This product is a cell cycle specific drug, which has a killing effect on all stages of proliferating cells, is the most sensitive to the S phase, and has a delaying effect on the G1/S boundary. Oral absorption is incomplete, and the drug is easy to inactivate in liver metabolism, and the blood drug concentration is relatively stable after intravenous drip or arterial perfusion.
fluorouracil has a significant effect on choriocarcinoma and malignant hydatidiform mole. It also has certain effects on gastric cancer, colon cancer, rectal cancer, esophageal cancer, liver cancer, pancreatic cancer, breast cancer, ovarian cancer, cervical cancer, prostate cancer, bladder cancer, kidney cancer, lung cancer, head and neck cancer, skin cancer, etc.
The role of purine, pyrimidine and other substances
Purines and pyrimidine are heterocyclic nitrogen-containing compounds necessary for nucleic acid metabolism in organisms (including humans). They are important substances that constitute ribonucleic acid and deoxyribonucleic acid in cells. Purines and pyrimidine combine with ribose and phosphate to form RNA; purines and pyrimidine combine with deoxyribose and phosphate to produce DNA. DNA is the main chemical component of genes, which plays an important role in gene transmission, that is, genetic function. The main role of RNA is to regulate the synthesis of proteins in cells. The final product of purine metabolism is mainly uric acid. Barley and malt contain 0.2% ~ 0.3% nucleic acid dry matter. During saccharification, they are degraded by various phosphatase enzymes to form a variety of degradation products such as nucleotides, nucleosides, purines and pyrimidines. Among them, only purines and pyrimidine enter Yeast cells constitute ribonucleic acid, deoxyribonucleic acid, adenosine triphosphate and certain coenzymes. Nucleotides are difficult to be absorbed. If the culture medium lacks purine and pyrimidine, it has to rely on carbohydrates and amino acids to synthesize, which will consume a lot of energy and affect the proliferation of yeast. Generally speaking, there is no shortage of purines and pyrimidines in wort.
Last Update：2024-04-09 20:52:54
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View History
嘧啶(阴凉)
DGTP[ALPHA-32P]
儿茶酚硼烷, 1.0 M 四氢呋喃溶液, J&KSEAL瓶
1-(5-氟吡啶-2-基)乙-1-胺二盐酸盐
(6R,7R)-7-[2-呋喃基(甲氧亚氨基)乙酰氨基]-3-氨基甲酰氧甲基-8-氧代-5-硫杂-1-氮杂二环[4.2.0]辛-2-烯-2-甲酸钠
D-2-AMINO CAPROIC ACID
9-均三甲苯基-10-甲基吖啶高氯酸盐
Maxilon Yellow M 4GL
2-环丁基甲基丙二酸
5-Bromobenzo[d]imidazol-2-one
DGTP[ALPHA-32P]
儿茶酚硼烷, 1.0 M 四氢呋喃溶液, J&KSEAL瓶
1-(5-氟吡啶-2-基)乙-1-胺二盐酸盐
(6R,7R)-7-[2-呋喃基(甲氧亚氨基)乙酰氨基]-3-氨基甲酰氧甲基-8-氧代-5-硫杂-1-氮杂二环[4.2.0]辛-2-烯-2-甲酸钠
D-2-AMINO CAPROIC ACID
9-均三甲苯基-10-甲基吖啶高氯酸盐
Maxilon Yellow M 4GL
2-环丁基甲基丙二酸
5-Bromobenzo[d]imidazol-2-one
Raw Materials for 嘧啶(阴凉)
Downstream Products for 嘧啶(阴凉)