Molecular Formula | C16H20O6 |
Molar Mass | 308.33 |
Density | 1.269±0.06 g/cm3(Predicted) |
Melting Point | 269-270°C |
Boling Point | 530.0±50.0 °C(Predicted) |
Specific Rotation(α) | (CHCl3)+55.9 |
Flash Point | 195.5°C |
Solubility | Soluble in chloroform, methanol |
Vapor Presure | 4.61E-12mmHg at 25°C |
Appearance | White powder or crystal |
pKa | 14.39±0.20(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.568 |
MDL | MFCD11042251 |
Physical and Chemical Properties | Light yellow crystalline powder, soluble in methanol, derived from Zanthoxylum nitidum, Feilong palm blood. |
In vitro study | Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1. |
overview | feilongzhang blood lactone, also known as nitidum, is a coumarin compound with a molecular formula of C16H20O6 and a molecular weight of 308.33. Zanthoxylum nitidum exists in Rutaceae (Rutaceae), Zanthoxylum bungeanum (Roxb.), Zanthoxylumnitidum(Roxb.)DC.), Zanthoxylum bungeanum (Zanthoxylumnitidumvar.fastuosum), and Toddaliaasiatica(L.)Lam.[PaulliniaasiaticaL.]). |
biological activity | Toddalolactone,Toddalia the main component of asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor -1 (PAI-1), IC50 is 37.31 μM. |
target | TargetValue PAI-1 () 37.31 μM |
Target | Value |
PAI-1 () | 37.31 μM |
in vitro study | Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1. |
chemical properties | light yellow crystalline powder, soluble in methanol, derived from Zanthoxylum nitidum, dragon palm blood. |
use | nitidum has anti-inflammatory, analgesic, anti-cancer and antispasmodic effects. used for content determination/identification/pharmacological experiment, etc. |