甲磺酸奈非那韦
Nelfinavir mesylate
CAS: 159989-65-8
Molecular Formula: C33H49N3O7S2
甲磺酸奈非那韦 - Names and Identifiers
| Name | Nelfinavir mesylate |
| Synonyms | AG-1343 viracept Nelfinavir1 NELFINAVIR MESYLATE Nelfinavir mesylate 8a-beta))-a-betmonomethanesulfonate(salt) droxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-,(3s-(2(2,s*,3s*),3-alpha,4 (3S,4AS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide (3s,4as,8as)-n-(1,1-dimethylethyl)decahydro-2-[(2r,3r)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide mesylate |
| CAS | 159989-65-8 |
| InChI | InChI=1/C32H45N3O4S.CH4O3S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4;1-5(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39);1H3,(H,2,3,4)/t22-,23+,26-,27-,29+;/m0./s1 |
| InChIKey | NQHXCOAXSHGTIA-SKXNDZRYSA-N |
甲磺酸奈非那韦 - Physico-chemical Properties
| Molecular Formula | C33H49N3O7S2 |
| Molar Mass | 663.89 |
| Melting Point | 131-135°C |
| Boling Point | 786.8℃ at 760 mmHg |
| Water Solubility | 4.5g/L(temperature not stated) |
| Solubility | DMSO: ≥2mg/mL |
| Appearance | A white or almost white powder. |
| Color | white to off-white |
| Merck | 14,6443 |
| pKa | pKa -1.20(at 25℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Use | Used as an antiviral drug |
| In vivo study | In vivo studies have shown that AG1343 is well absorbed after oral administration in multiple species and has a favorable pharmacokinetic profile in humans. In fed rats, the oral bioavailability of the compound was 43%, while in fasted rats, the oral bioavailability decreased significantly to 29%. In a variety of organisms, the oral bioavailability of Nelfinavir is 47% in dogs, 17% in marmosets and 26% in cynomolgus monkeys. After oral administration, it has a longer half-life in plasma, which may be due to slower decomposition and absorption. In humans, Nelfinavir can be well absorbed, especially when administered with food, with relatively few, easy to handle side effects, and good safety. |
甲磺酸奈非那韦 - Risk and Safety
| WGK Germany | 3 |
| RTECS | NW6995333 |
| HS Code | 29334900 |
甲磺酸奈非那韦 - Introduction
Nelfinavir Mesylate is a potent HIV protease inhibitor with a Ki of 2 nM.
Last Update：2022-10-16 17:14:12
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View History
甲磺酸奈非那韦
DELTA 9 CIS HEXADECENOIC ACID METHYL ESTER
氯化花翠素葡萄糖苷
BOC-(S)-2-AMINO-2-METHYL-3-PHENYLPROPANOIC ACID
4,4'-Azobis(4-cyanovaleric acid)
1-MONO-TRANS-9-OCTADECENOYL GLYCEROL
cis-.beta.-Methylstyrene
三乙撑二胺
SETACYL RED 2B
6-氨基-5-溴吡啶-2-羧酸甲酯
DELTA 9 CIS HEXADECENOIC ACID METHYL ESTER
氯化花翠素葡萄糖苷
BOC-(S)-2-AMINO-2-METHYL-3-PHENYLPROPANOIC ACID
4,4'-Azobis(4-cyanovaleric acid)
1-MONO-TRANS-9-OCTADECENOYL GLYCEROL
cis-.beta.-Methylstyrene
三乙撑二胺
SETACYL RED 2B
6-氨基-5-溴吡啶-2-羧酸甲酯