补骨脂提取物
补骨脂提取物
CAS: 66-97-7
Molecular Formula: C11H6O3
补骨脂提取物 - Names and Identifiers
| Name | 补骨脂提取物 |
| Synonyms | PSORALEN Furo(4',5',6,7)coumarin furo(2',3',7,6)coumarin Fructus Psoraleae extract Psoralea corylifolia Linn. Extract Psoralen oil |
| CAS | 66-97-7 |
| EINECS | 200-639-7 |
| InChIKey | ZCCUUQDIBDJBTK-UHFFFAOYSA-N |
补骨脂提取物 - Physico-chemical Properties
| Molecular Formula | C11H6O3 |
| Molar Mass | 186.16 |
| Density | 1.2477 (rough estimate) |
| Melting Point | 160-162°C |
| Boling Point | 280.64°C (rough estimate) |
| Water Solubility | 65.16mg/L(25 ºC) |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Appearance | neat |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['328nm(EtOH)(lit.)'] |
| Merck | 14,7928 |
| BRN | 152784 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6310 (estimate) |
| Physical and Chemical Properties | Derived from legume psoralea Psoralea corylifolia l. fruit |
补骨脂提取物 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | LV0944000 |
| FLUKA BRAND F CODES | 8-10 |
| HS Code | 29339900 |
补骨脂提取物 - Pharmacology
Open Data Unverified Data
1. Psoralea has a significant dilation effect on tracheal contraction caused by histamine.
2. Psoralen has estrogenic effects, which can enhance vaginal keratinization and increase uterine weight.
3. Psoralea can regulate the nervous and blood systems, promote bone marrow hematopoiesis, enhance immune and endocrine functions, and thus exert anti-aging effects.
Last Update：2024-04-09 19:43:38
补骨脂提取物 - Function and efficacy
Open Data Unverified Data
Psoralea has the effects of tonifying the kidney and strengthening yang, consolidating essence and reducing urine, warming the spleen and stopping diarrhea, and absorbing qi and relieving asthma. Indications: Kidney deficiency and impotence, cold pain in the waist and knees, kidney deficiency and ejaculation, enuresis, frequent urination, spleen and kidney yang deficiency, diarrhea during the fifth shift, inability to absorb qi in the kidneys, deficiency cold asthma and cough:
1. Kidney deficiency, impotence, and cold pain in the waist and knees: This product is bitter, bitter, warm, and dry, and is good at strengthening the kidney yang and warming the water organs.
2. Kidney deficiency and enuresis, enuresis, and frequent urination: This product has both astringency and is good at tonifying the kidney and supporting yang, consolidating essence and reducing urine. It is effective when used alone, and can also be combined with other drugs according to the syndrome.
3. Spleen and kidney yang deficiency, five changes diarrhea: This product can strengthen kidney yang, warm spleen yang, and relieve astringency to stop diarrhea.
4. Kidney unable to absorb qi, deficiency cold asthma and cough: This product tonifies the kidney, helps yang, and absorbs qi to relieve asthma.
Last Update：2024-04-09 19:43:38
补骨脂提取物 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Overview | Psoralea corylifolia L., also known as nigroseed, broken paper, Hu Wei Zi, etc., was first recorded in the "open baby herbs". It is the legume Psoralea corylifolia L. The dry mature fruit, mainly produced in Sichuan, Henan, Shaanxi, Anhui and other places, the main chemical components of Psoralea corylifolia are pepper toxin, volatile oil, fatty oil, resin and psoralen, isopsoralen, psoralen, isopsoralidine, dihydroxyisopsoralidine, flavonoids (psoralen A, psoralen B, psoralen, new psoralen chalcone), monoterpene phenols (psoralen, etc.), coumarin. Psoralea corylifolia has the function of warming kidney, promoting Yang, promoting Qi and stopping diarrhea. Traditional Chinese medicine is used to treat impotence, enuresis, frequent micturition, cold pain of waist and knee, kidney deficiency for asthma, five more diarrhea and so on. Modern pharmacological studies have found that Psoralea corylifolia also has multiple pharmacological activities, such as anti-tumor, treatment of osteoporosis, estrogen-like effect, antibacterial and treatment of vitiligo. Psoralen, also known as psoralen, is an active ingredient extracted from plant Psoralea corylifolia, which belongs to furan coumarin. It has the effect of promoting the increase of skin melanin, and is clinically used for the treatment of vitiligo, alopecia areata and psoriasis. |
| pharmacological action | psoralen has the effect of increasing melanin. Under the irradiation of ultraviolet lamp, the phototoxic reaction can be generated, and the synthesis of DNA in epidermal cells can be selectively inhibited. |
| anticancer effect | psoralen has significant inhibitory effect on S180, Ehrlich ascites carcinoma and liver cancer H-22. Psoralen and 8-Methoxypsoralen have significant killing effect on S180 ascites cells. Both psoralen B and volatile oil have anti-cancer effects. |
| morphology of Psoralea corylifolia | Psoralea corylifolia is an annual herb, 0.5-1.5m in height, with white pilose and black-brown glandular spots. Stems were upright, branches were firm. Alternate leaves, with one lateral leaflet at the end of the branch and sometimes about 1cm in length. The leaf blade was broadly ovoid, 6-9cm in length and 5-7cm in width, the petiole was 2-4cm in length, and the lateral petioles were very short. Racemes were extracted from leaf axillae in summer, the total pedicels were very long, most of them were small flowers, with dense upper part, with head-like shape, the pedicel was short, and the Calyx was bell-shaped, flag lobe broadly obovoid; Stamens 10. Pod Oval-ovoid, about 5mm in length, black, not dehiscence at maturity. 1 seed, oblate, brown-black, attached to the Peel, with aroma. Fruit branches are picked in autumn, dried in the sun, and the fruits are rubbed out to remove impurities. Wash when used. Figure 1 extraction and separation of psoralen |
| indication | for vitiligo, psoriasis, alopecia areata, etc. Treatment of vitiligo: intramuscular injection, 2ml,1 times/d, can be used for several months. About 1h after the injection should be to the outdoor Sun 10~30min; Or with ultraviolet light distance 50cm irradiation, starting from 1~2min, daily or every other day increased by 1min, gradually increased to 10~15min. Apply the solution for external use to the affected area, starting from a small area, after a few minutes to the outdoor sun, starting from 5min, if there is no allergic reaction, can gradually increase to 20min/time; can also be irradiated with ultraviolet light, the method with intramuscular injection. Every 2~3 days to apply 1 times, adhere to a number of years or more than half a year. Large area of the patient can be intramuscular injection and external use at the same time. Treatment of psoriasis: oral, 40~80mg/Time, 2H after the whole body black light. When the projection distance was 7 ~ 17cm, the irradiation time was 15~30min. For the stubborn part of skin lesion, the distance should be short. 1 times/ (1~2) d. After the basic cure, should continue to consolidate treatment, and gradually extend the treatment time. |
| extraction | FIG. 2 extraction |
| contraindication | 1.12 children under the age of, the frail elderly and pregnant women are contraindicated. There are photosensitive diseases such as lupus erythematosus, Dermatomyositis, porphyria, polymorphic light rash, xeroderma pigmentosum and other patients disabled. Disabled in patients with severe liver disease. 4. Cataract or other lens disease patients disabled. (2015-12-28) |
| adverse reactions | the affected part may have redness, swelling and blisters after sun exposure and ultraviolet irradiation. |
| note | 1. Should wear dark glasses protection after using this product. Treatment of erythema, blisters, treatment should be suspended, after the resumption of treatment, but the sun and ultraviolet irradiation time should be shortened. 3. Injection such as precipitation of crystals, can be put in boiling water for 10 minutes, to be dissolved in the crystal and cool after use. |
| Use | has the effect of increasing skin melanin, and is suitable for vitiligo. In addition, it can be used for alopecia areata and psoriasis. phototoxic phytoalexin; When activated by UV light, psoralen induces cross-linking across strands in DNA. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:55
