雷洛西芬
Raloxifene
CAS: 84449-90-1
Molecular Formula: C28H27NO4S
雷洛西芬 - Names and Identifiers
| Name | Raloxifene |
| Synonyms | Evista RALOXAFINE Raloxifene [4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl] ketone Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]- [6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone hydrochloride |
| CAS | 84449-90-1 |
| EINECS | 686-786-1 |
| InChI | InChI=1/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2 |
雷洛西芬 - Physico-chemical Properties
| Molecular Formula | C28H27NO4S |
| Molar Mass | 473.58 |
| Density | 1.289±0.06 g/cm3(Predicted) |
| Melting Point | 250-253°C |
| Boling Point | 728.2±60.0 °C(Predicted) |
| Water Solubility | 560μg/L at 25℃ |
| Solubility | DMSO: 28mg/mL, soluble |
| Appearance | solid |
| Color | light yellow |
| pKa | 8.83±0.15(Predicted) |
| Storage Condition | Desiccate at +4°C |
| Physical and Chemical Properties | Crystallization from acetone, melting point 143-147 °c. UV absorption maximum (ethanol):290nm (λ34000). Raloxifene Hydrochloride: C28H27NO4S? HCl. [8264000408]. Crystallization from methanol-water, melting point 258 °c. UV absorption maximum (ethanol):286NM (λ328 00). |
雷洛西芬 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29349990 |
雷洛西芬 - Nature
Open Data Verified Data
crystallized from acetone, melting point 143-147 °c. UV absorption maximum (ethanol);290nm(e34000).
Last Update：2024-01-02 23:10:35
雷洛西芬 - Preparation Method
Open Data Verified Data
2 (4-hydroxyphenyl) benzo [B] thiophene-6 monoalcohol is esterified with methanesulfonyl chloride to produce Diester with 4-(2-piperidinyl ethoxy) benzoyl chloride is subjected to acylation reaction, and raloxifene is obtained by hydrolysis.
Last Update：2022-01-01 09:24:21
雷洛西芬 - Use
Open Data Verified Data
It was developed by the U. S. Lily and company and was launched in the United States in January 1998. Estrogen receptor modulators, in the uterus and breast tissue showed antagonistic estrogen effect, inhibition of mammary epithelial and endometrial hyperplasia. In the aspect of bone lipid metabolism showed Excitatory effect, with the role of estrogen. The combination of raloxifene and calcium preparations can prevent bone loss, maintain bone density and reduce blood wax.
Last Update：2022-01-01 09:24:21
Supplier List
Multiple SpecificationsSpot supply
Product Name: Keoxifene; LY156758 free base; LY139481 Visit Supplier Webpage Request for quotationCAS: 84449-90-1
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Product Name: Raloxifene Visit Supplier Webpage Request for quotationCAS: 84449-90-1
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Multiple SpecificationsSpot supply
Product Name: Keoxifene; LY156758 free base; LY139481 Visit Supplier Webpage Request for quotationCAS: 84449-90-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Raloxifene Visit Supplier Webpage Request for quotationCAS: 84449-90-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Raloxifene Visit Supplier Webpage Request for quotationCAS: 84449-90-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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View History
雷洛西芬
3-氨基-3-乙氧基丙烯酸乙酯盐酸
甲磺酸达比加群酯杂质K
Cobalt Carbonate
N-(4-羟基丁基)氨基甲酸苄酯
DIISOPROPYLMETHYLAMINE
HYDROCHLORIC ACID (SUBBOILING DISTILLED ACID) 1L
双丙酮-D-甘露糖醇
4-METHOXYPHENYLACETYL CHLORIDE
氰化高汞
3-氨基-3-乙氧基丙烯酸乙酯盐酸
甲磺酸达比加群酯杂质K
Cobalt Carbonate
N-(4-羟基丁基)氨基甲酸苄酯
DIISOPROPYLMETHYLAMINE
HYDROCHLORIC ACID (SUBBOILING DISTILLED ACID) 1L
双丙酮-D-甘露糖醇
4-METHOXYPHENYLACETYL CHLORIDE
氰化高汞