MFH290 MedChemExpress (MCE)

Product Name	2-Propenamide, N-[4-[[(3R)-3-[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]-1-piperidinyl]carbonyl]phenyl]-
Synonyms	2-Propenamide, N-[4-[[(3R)-3-[[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]amino]-1-piperidinyl]carbonyl]phenyl]-;MFH290
CAS	2088715-91-5
EINECS
Chemical Formula	C26H31N5O3S2
Molecular Weight	525.69
inchi
Package	1 mg
Price	Email to quote
Descriptions	MFH290 MFH290 MedChemExpress (MCE) HY-153244 2088715-91-5 98.07% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions MFH290 MFH290 MedChemExpress (MCE) HY-153244 2088715-91-5 98.07% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. MFH290 is a potent and highly selective cyclin-dependent kinase 12/13 (CDK12/13) covalent inhibitor. MFH290 forms a covalent bond with Cys-1039 of CDK12 and exhibits excellent kinome selectivity and inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II). MFH290 is used for cancer research. IC50: CDK12/13 Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Yao Liu, et al. Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem. 2020 Jul 9 63(13):6708-6726. [Content Brief] [2]. Yao Liu, et al. Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem. 2020 Jul 9 63(13):6708-6726. [Content Brief]
Last Update	2025-04-01 14:45:47

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