Thalidomide-NH-PEG3-NH-Boc MedChemExpress (MCE)

Product Name	5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-, 1,1-dimethylethyl ester
Synonyms	Thalidomide-NH-PEG3-NH-Boc TERT-BUTYL (2-(2-(2-(2-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-4-YL)AMINO)ETHOXY)ETHOXY)ET tert-Butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)carbamate Synonyms Thalidomide-NH-PEG3-NH-Boc TERT-BUTYL (2-(2-(2-(2-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-4-YL)AMINO)ETHOXY)ETHOXY)ET tert-Butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)carbamate 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-, 1,1-dimethylethyl ester
CAS	2204246-03-5
EINECS
Chemical Formula	C26H36N4O9
Molecular Weight	548.59
inchi
Package	5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Thalidomide-NH-PEG3-NH-Boc Thalidomide-NH-PEG3-NH-Boc MedChemExpress (MCE) HY-44063 2204246-03-5 97.20% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Thalidomide-NH-PEG3-NH-Boc Thalidomide-NH-PEG3-NH-Boc MedChemExpress (MCE) HY-44063 2204246-03-5 97.20% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Thalidomide-NH-PEG3-NH-Boc is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-NH-PEG3-NH-Boc acts as a ligand for Cereblon to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-PEG3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-PEG3-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules. Cereblon \| \| \| \| \| \| \| \| \| \| [1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7 512(7512):49-53. [Content Brief] [Content Brief]
Supplier Website	https://www.medchemexpress.com/thalidomide-nh-peg3-nh-boc.html
Last Update	2025-05-21 16:50:25

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