Hydrocortisone 21-hemisuccinate sodium MedChemExpress (MCE)

Product Name	Hydrocortisone Sodium Succinate
Synonyms	Hydorcortisone Sodium Succinate Hydrocortisone Sodium Succinate HYDROCORTISONE SODIUM SUCCINATE Hydrocortisone-21-sodium Succinate HYDROCORTISONE 21-HEMISUCCINATE SODIUM HYDROCORTISONE HEMISUCCINATE SODIUM SALT Synonyms Hydorcortisone Sodium Succinate Hydrocortisone Sodium Succinate HYDROCORTISONE SODIUM SUCCINATE Hydrocortisone-21-sodium Succinate HYDROCORTISONE 21-HEMISUCCINATE SODIUM HYDROCORTISONE HEMISUCCINATE SODIUM SALT HYDROCORTISONE 21-HEMISUCCINATE SODIUM SALT HYDROCORTISONE-HYDROGEN SUCCINATE SODIUM SALT 11b,17a,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt sodium 4-[(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoate 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT sodium 4-{[(11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoate 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM-POTASSIUM SALT
CAS	125-04-2
EINECS	204-725-5
Chemical Formula	C25H33O8.Na
Molecular Weight	484.52
inchi	InChI=1/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30 /h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30) /q +1/p-1/t16-,17-,18-,22+,23-,24-,25- inchi InChI=1/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30 /h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30) /q +1/p-1/t16-,17-,18-,22+,23-,24-,25- /m0./s1
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Hydrocortisone hemisuccinate sodium Hydrocortisone hemisuccinate sodium MedChemExpress (MCE) HY-B1402B 125-04-2 Hydrocortisone 21-hemisuccinate sodium 99.66% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Hydrocortisone hemisuccinate sodium Hydrocortisone hemisuccinate sodium MedChemExpress (MCE) HY-B1402B 125-04-2 Hydrocortisone 21-hemisuccinate sodium 99.66% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC). Hydrocortisone hemisuccinate sodium inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3]. Hydrocortisone hemisuccinate sodium (0.12-60 μM 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3]. Hydrocortisone hemisuccinate sodium (30 mg/kg p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2]. \| \| \| \| \| \| \| \| \| \| [1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun 24(6):701-3. [Content Brief] [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5 130:243-53. [Content Brief] [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987 9(4):469-73. [Content Brief]
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Last Update	2025-05-21 16:50:25

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