NX-13 MedChemExpress (MCE)

Product Name	1,3,5-tris((6-methylpyridin-2-yl)oxy)benzene
Synonyms	AMELENODOR;1,3,5-tris((6-methylpyridin-2-yl)oxy)benzene
CAS	2389235-01-0
EINECS
Chemical Formula	C24H21N3O3
Molecular Weight	399.44
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Amelenodor Amelenodor MedChemExpress (MCE) HY-141521 2389235-01-0 NX-13 98.47% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Amelenodor Amelenodor MedChemExpress (MCE) HY-141521 2389235-01-0 NX-13 98.47% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. NX-13 is a first-in-class, orally active and gut-restricted agent that selectively targets and activates the NLRX1 pathway to induce immunometabolic changes. NX-13 results in lower inflammation and responses in inflammatory bowel disease. NX-13 can be used for the research of crohn's disease and ulcerative colitis. NX-13 (0, 500, or 1000 mg/kg oral gavage 7 days) reduces ALP levels[2]. NX-13 (1 and 10 mg/kg oral gavage 0~24 hours) reaches the distal gastrointestinal tract[2]. NLRX1[1] In Vivo NX-13 (0, 500, or 1000 mg/kg oral gavage 7 days) reduces ALP levels[2]. NX-13 (1 and 10 mg/kg oral gavage 0~24 hours) reaches the distal gastrointestinal tract[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague Dawley rats (six weeks age)[2] \| \| \| \| \| \| \| \| \| \| [1]. Leber A, et al. Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells. J Immunol. 2019 203(12):3407-3415. [Content Brief] [2]. Leber A, et.al. Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1 [published online ahead of print, 2019 Oct 25]. Drug Chem Toxicol. 2019 1-6. [Content Brief]
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Last Update	2025-05-21 16:50:25

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