BTCA MedChemExpress (MCE)

Product Name	benzo[d]oxazole-6-carboxylic acid
Synonyms	6-Benzoxazolecarboxylic acid;Benzoxazole-6-carboxylic Acid;benzo[d]oxazole-6-carboxylic acid;1,3-Benzoxazole-6-carboxylic acid
CAS	154235-77-5
EINECS
Chemical Formula	C8H5NO3
Molecular Weight	163.13
inchi
Package	10 mM * 1 mL;1 g;5 g
Price	Email to quote
Descriptions	Serpin B9-IN-1 Serpin B9-IN-1 MedChemExpress (MCE) HY-33299 154235-77-5 BTCA 97.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Serpin B9-IN-1 Serpin B9-IN-1 MedChemExpress (MCE) HY-33299 154235-77-5 BTCA 97.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9) SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM). Serpin B9-IN-1 (BTCA) inhibits bone metastasis (BM) in multiple tumor metastasis models. Serpin B9-IN-1 (50 mg/kg/d ip 14 d) effectively reduced the survival rate and metastasis proportion of metastatic cancer cells in the mouse bone metastasis model with LLC1-BM3 injected into the tail artery (CA)[1].Serpin B9-IN-1 (300 μg/d ip 14 d) effectively delayed the average time to bone metastasis (BM) in the LLC1-BM3 cell group[1]. IC50: Serpin B9 In Vivo Serpin B9-IN-1 (BTCA) inhibits bone metastasis (BM) in multiple tumor metastasis models. Serpin B9-IN-1 (50 mg/kg/d ip 14 d) effectively reduced the survival rate and metastasis proportion of metastatic cancer cells in the mouse bone metastasis model with LLC1-BM3 injected into the tail artery (CA)[1].Serpin B9-IN-1 (300 μg/d ip 14 d) effectively delayed the average time to bone metastasis (BM) in the LLC1-BM3 cell group[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: LLC1-BM3 Bone Metastatic Mouse Model by CA injections[1] \| \| \| \| \| \| \| \| \| \| [1]. Huang Y, et al. Mass Spectrometry-Based Proteomics Identifies Serpin B9 as a Key Protein in Promoting Bone Metastases in Lung Cancer. Mol Cancer Res. 2024 Apr 2 22(4):402-414. [Content Brief]
Last Update	2025-04-01 14:45:47

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