ZM 449829 MedChemExpress (MCE)

Product Name	ZM 449829
Synonyms	ZM 449829;JAK3 INHIBITOR V;2-Acrylonaphthone;2-NAPHTHYLVINYL KETONE;1-Naphthalen-2-yl-propenone;1-(2-Naphthyl)-2-propen-1-one;1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE;2-Propen-1-one, 1-(2-naphthalenyl)-
CAS	4452-06-6
EINECS
Chemical Formula	C13H10O
Molecular Weight	182.22
inchi
Package	5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	ZM 449829 ZM 449829 MedChemExpress (MCE) HY-13450 4452-06-6 99.73% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions ZM 449829 ZM 449829 MedChemExpress (MCE) HY-13450 4452-06-6 99.73% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3. ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 [1]. ZM449829 (1 μM 30 minutes) blocks IL-2-induced STAT5 phosphorylation[2]. JAK3 6.8 (pIC50) JAK1 4.7 (pIC50) EGFR 5.0 (pIC50) \| \| \| \| \| \| \| \| \| \| [1]. Brown GR, et, al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 2010(6)575-9. [Content Brief] [2]. Orange JS, et, al. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J Clin Invest. 2011 Apr 121(4): 1535-48. [Content Brief]
Last Update	2025-04-01 14:45:47

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