Bepotastine MedChemExpress (MCE)

Product Name	Bepotastine Besilate
Synonyms	Talion (TN) Bepotastine besylate BEPOTASTINE BESILATE Bepotastine Beslilat Bepotastine Besilate Bepotastine Besylate 4-[4-[(R)-(4-chlorophenyl)-pyridin-2-yl-methoxy]-1-piperidyl]butanoic acid Synonyms Talion (TN) Bepotastine besylate BEPOTASTINE BESILATE Bepotastine Beslilat Bepotastine Besilate Bepotastine Besylate 4-[4-[(R)-(4-chlorophenyl)-pyridin-2-yl-methoxy]-1-piperidyl]butanoic acid 4-((4-Chlorophenyl)-2-pyridinylmethoxy)- (S)-1-piperidinebutanoic acid monobenzenesulfonate 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, monobenzenesulfonate (+)-(S)-4-(4-((4-Chlorophenyl)(2-pyridyl)methoxy)piperidino)butyric acid monobenzenesulfonate 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-, monobenzenesulfonate 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (S)-, monobenzenesulfonate
CAS	190786-44-8;190730-42-8
EINECS	1806241-263-5
Chemical Formula	C27H31ClN2O6S
Molecular Weight	547.07
inchi	InChI=1/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26 7-10(8,9)6-4-2-1-3-5-6/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26) 1-5H,(H,7,8,9)/t21- inchi InChI=1/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26 7-10(8,9)6-4-2-1-3-5-6/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26) 1-5H,(H,7,8,9)/t21- /m1./s1
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Bepotastine besilate Bepotastine besilate MedChemExpress (MCE) HY-A0015 190786-44-8 99.77% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Bepotastine besilate Bepotastine besilate MedChemExpress (MCE) HY-A0015 190786-44-8 99.77% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research. Bepotastine besilate (10, 100, 1000 μM preincubates for 120 min) decreases the release of histamine induced by A23187 treatment, which reaches a statistically significant reduces level at 1000 μM[1]. Bepotastine besilate (50 μM 1 h) suppresses the expression of NGF mRNA in NHEKs[2]. Bepotastine besilate (10 g/L eye drop 3 times at intervals of 20 min in one eye) demonstrates significant inhibition of PAF-induced conjunctival eosinophil infiltration[1]. Bepotastine besilate (3 mg/kg p.o. once) suppresses scratching behavior to a frequency of 59.0 and a duration of 14.57 seconds, which are almost the same levels compares with the control[3]. Bepotastine besilate (10 mg/kg p.o. once) significantly suppresses serum LTB 4 levels to 711.3 pg/mL at 1 h and 858.8 pg/mL at 2 h in NC/Nga mice with a rash[3]. H1 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Kida T, et al. Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul 91(1):85-91. [Content Brief] [2]. Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811(18)30186-5. [Content Brief] [3]. Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008 145(4):277-82. [Content Brief] [4]. Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct 26(10):2329-38. [Content Brief]
Last Update	2025-04-01 14:45:47

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