22-Oxacalcitriol MedChemExpress (MCE)

Product Name	Maxacalcitol
Synonyms	MAXACALCITOL Maxacalcitol Oxacalcitriol 22-Oxa-1α,25-dihydroxycholecalciferol (5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol (1S,3R,5Z,7E,9xi,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol Synonyms MAXACALCITOL Maxacalcitol Oxacalcitriol 22-Oxa-1α,25-dihydroxycholecalciferol (5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol (1S,3R,5Z,7E,9xi,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol (+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)- (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CAS	103909-75-7
EINECS	234-317-2
Chemical Formula	C26H42O4
Molecular Weight	418.61
inchi	InChI=1/C26H42O4/c1-17-20(15-21(27)16-24(17)28)9-8-19-7-6-12-26(5)22(10-11-23(19)26)18(2)30-14-13-25(3,4)29/h8-9,18,21-24,27-29H,1,6-7,10-16H2,2-5H3/b19-8+,20-9-/t18-,21+,22+,23-,24-,26+/m0/s1
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Maxacalcitol Maxacalcitol MedChemExpress (MCE) HY-32339 103909-75-7 22-Oxacalcitriol 98.99% 4°C, protect from light, stored under nitrogen The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US Descriptions Maxacalcitol Maxacalcitol MedChemExpress (MCE) HY-32339 103909-75-7 22-Oxacalcitriol 98.99% 4°C, protect from light, stored under nitrogen The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. Maxacalcitol (22-Oxacalcitriol), a vitamin D3 (HY-15398) analog, is an orally active VDR agonist. Maxacalcitol has a limited calcemic effect. Maxacalcitol has the potential for psoriasis and hyperparathyroidism research. Maxacalcitol (22-Oxacalcitriol 100 nM for 24 h) markedly increases the expression of LL-37 mRNA in Ca9-22 cells and modestly but significantly increases in HSC-2, HSC-3, and HSC-4 cells[1]. Maxacalcitol (22-Oxacalcitriol oral gavage 15 µg/kg/day 14 days) followed by GSK 269962 at a single dose of 10 mg/kg, leads to a statistically significant reduction of intercontraction interval and bladder compliance, and an increase in DO index, without any effect on ANVC, FNVC, and VTNVC[2]. Maxacalcitol in a dose of 30 but not 15 µg/kg/day induced reduction in detrusor overactivity (DO) index, non-voiding contractions frequency (FNVC), and amplitude (ANVC), while increasing volume threshold to elicit non-voiding contractions (VTNVC)[2]. \| \| \| \| \| \| \| \| \| \| [1]. Hiroyuki Tada, et al. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res. 2016 37(3):199-205. [Content Brief] [2]. Andrzej Wróbel, et al. The Influence of Maxacalcitol, Vitamin D3 Analog, on Detrusor Overactivity in Conscious Rats. Urology. 2016 Jul:93:224.e7-224.e15. [Content Brief] [3]. Masaru Karakawa, et al. Effects of maxacalcitol ointment on skin lesions in patients with psoriasis receiving treatment with adalimumab. J Dermatol. 2016 Nov 43(11):1354-1357. [Content Brief]
Last Update	2025-04-01 14:45:47

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