LGD1069 MedChemExpress (MCE)

Product Name	Bexarotene
Synonyms	LG 69 LGD1069 Targret SR 11247 Targretin Bexarotene RO 26-4455 Synonyms LG 69 LGD1069 Targret SR 11247 Targretin Bexarotene RO 26-4455 Bexzarotene 1-Bexarotene Bexarotene, Free 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid Bexarotene(4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoic acid 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid, SR-11247, LGD-1069, Targretin
CAS	153559-49-0
EINECS
Chemical Formula	C24H28O2
Molecular Weight	348.48
inchi	InChI=1/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
Package	10 mM * 1 mL;10 mg;25 mg;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	Bexarotene Bexarotene MedChemExpress (MCE) HY-14171 153559-49-0 LGD1069 99.92% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Bexarotene Bexarotene MedChemExpress (MCE) HY-14171 153559-49-0 LGD1069 99.92% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM). Bexarotene can be used for the research of cutaneous T-cell lymphoma. Bexarotene selectively binds and activates RXR subtypes with Kd=14±2 nM, 21±4 nM, and 29±7 nM for RXRα, RXRβ, and RXRγ subtypes[1]. Bexarotene is effective in limiting the proliferation of leukemic (HL-60) cells. Bexarotene inhibits the proliferation of HL-60 cells by 37% at 1 μM[1]. Bexarotene monotherapy of cells shows an antiproliferative effect at a high dose, and the IC50s aere 40.62±0.45 μM (PC3) and 50.20±4.10 μM (DU145)[2]. Bexarotene (20 and 40 μM) and Docetaxel (5 and 10 μM) exhibit a synergistic effect on the inhibition of PC3 and DU145 cell proliferation[2].Bexarotene (20 and 40 μM) represses cyclin D1 and cyclin D3 expression in PC3 and DU145 cells[2]. Bexarotene (1 mg/kg/day) is effective in blocking the development of behavioral deficits and dopamine neuron degeneration in a rat model of Parkinson’s disease (PD) producing significantly reduced changes in both triglycerides and T4 serum[1]. Bexarotene is an effective preventive agent against lung tumor growth and progression. Bexarotene (100 mg/kg by gavage) inhibits both tumor multiplicity and tumor volume in mice of all three genotypes (p53wt/wtK-raswt/wt, p53val135/wtK-raswt/wt, or p53wt/wtK-rasko/wt). Bexarotene reduces the progression of adenoma to adenocarcinoma by ～50% in both p53wt/wtK-rasko/wt and p53wt/wtK-raswt/wt mice[3]. \| \| \| \| \| \| \| \| \| \| [1]. Nathalia Rodrigues de Almeida, et al. A review of the molecular design and biological activities of RXR agonists. Med Res Rev. 2019 Jul 39(4):1372-1397. [Content Brief] [2]. Danyang Shen, et al. Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer. Onco Targets Ther. 2019 Sep 24 12:7877-7886. [Content Brief] [3]. Y Wang, et al. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene. 2006 Mar 2 25(9):1320-9. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Bexarotene.html
Last Update	2025-05-21 16:50:25

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