SR 141716A Hydrochloride MedChemExpress (MCE)

Product Name	Rimonabant hydrochloride
Synonyms	ACOMPLIA Rimonabant HCl RIMONABANT HCL Rimonabant hcl Acomplia, SR141716 Rimonabant(Acomplia) ACOMPLIA (RIMONABANT Synonyms ACOMPLIA Rimonabant HCl RIMONABANT HCL Rimonabant hcl Acomplia, SR141716 Rimonabant(Acomplia) ACOMPLIA (RIMONABANT RIMONABANT HYDROCHLORIDE Rimonabant hydrochloride RimonabantConsultedStandard N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide monohydrochloride 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-, monohydrochloride
CAS	158681-13-1
EINECS	233-720-0
Chemical Formula	C22H21Cl3N4O.ClH
Molecular Weight	500.25
inchi	InChI=1/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Rimonabant Hydrochloride Rimonabant Hydrochloride MedChemExpress (MCE) HY-14137 158681-13-1 SR 141716A Hydrochloride 99.31% 4°C, sealed storage, away from moisture In solvent : -80°C, 1 year Descriptions Rimonabant Hydrochloride Rimonabant Hydrochloride MedChemExpress (MCE) HY-14137 158681-13-1 SR 141716A Hydrochloride 99.31% 4°C, sealed storage, away from moisture In solvent : -80°C, 1 year -20°C, 6 months (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant[2]. Rimonabant itself (10-12-10-3 M, 12 concentrations) inhibits the basal binding of [35S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC50 of 4.7±0.2 (IC50 = 20 μM) and a maximal inhibition of 48±2%[3]. Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant[1]. Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors[4]. CB1 1.8 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct 63(5):905-15. [Content Brief] [2]. Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24 176(3):636-648.e13. [Content Brief] [3]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268. [Content Brief]
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Last Update	2025-05-21 16:50:25

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