RI-1 MedChemExpress (MCE)

Product Name	RI-1
Synonyms	RI1 RI-1 RAD51 inhibitor 1 RAD51 inhibitor RI-1 3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-
CAS	415713-60-9
EINECS
Chemical Formula	C14H11Cl3N2O3
Molecular Weight	361.61
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	RI-1 RI-1 MedChemExpress (MCE) HY-15317 415713-60-9 99.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions RI-1 RI-1 MedChemExpress (MCE) HY-15317 415713-60-9 99.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells. RI-1 (1-50 μM 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells[1].?RI-1 (5-20 μM 30 min) inhibits HsRAD51 in a concentration-dependent manner[1].?RI-1 (20 μM 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts[1].?RI-1 (15-25 μM 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy[1]. RI-1 (50 mg/kg i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice[2]. IC50: 5-30 μM (RAD51)[1] In Vitro RI-1 (1-50 μM 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells[1].?RI-1 (5-20 μM 30 min) inhibits HsRAD51 in a concentration-dependent manner[1].?RI-1 (20 μM 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts[1].?RI-1 (15-25 μM 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> RI-1 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Budke B, et, al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug 40(15):7347-57. [Content Brief] [2]. Shi Y, et, al. DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia. 2019 Jun 21(6):533-544. [Content Brief]
Last Update	2025-04-01 14:45:47

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