OPC-14597 MedChemExpress (MCE)

Product Name	Aripiprazole
Synonyms	OPC 31 ABILIFY ABILITAT OPC 14597 Aripiprazole ARIPIPRAZOLE ARIPIPRAZOLE-D8 Synonyms OPC 31 ABILIFY ABILITAT OPC 14597 Aripiprazole ARIPIPRAZOLE ARIPIPRAZOLE-D8 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
CAS	129722-12-9
EINECS	603-355-5
Chemical Formula	C23H27Cl2N3O2
Molecular Weight	448.39
inchi	InChI=1/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Package	10 mM * 1 mL;100 mg;200 mg
Price	Email to quote
Descriptions	Aripiprazole Aripiprazole MedChemExpress (MCE) HY-14546 129722-12-9 OPC-14597 99.95% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Aripiprazole Aripiprazole MedChemExpress (MCE) HY-14546 129722-12-9 OPC-14597 99.95% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19. Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation[1]. Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine[3]. Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties[4]. 5-HT1A Receptor 4.2 nM (Ki) 5-HT2A Receptor 5-HT2B Receptor 5-HT2C Receptor D2 Receptor D3 Receptor D4 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Burris KD, et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul 302(1):381-9. [Content Brief] [2]. Davies MA, et al. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 2004 Winter 10(4):317-36. [Content Brief] [3]. Crespo-Facorro B, et al. Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis. Front Pharmacol. 2021 Mar 2 12:646701. [Content Brief] [4]. Russo E, et al. Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity. Neuropharmacology. 2013 Jan 64:371-9. [Content Brief] [5]. Stip E, et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010 32 Suppl 1:S3-20. [Content Brief]
Last Update	2025-04-01 14:45:47

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