Loteprednol Etabonate MedChemExpress (MCE)

Product Name	Loteprednol Etabonate
Synonyms	Lotemax Loteprednol Etabonate Lotoprednol etabonate LOTEPREDNOL ETABONATE CDDD-5604, HGP-1, P-5604, Alrex, Lotemax 3-Oxo-11β-hydroxy-17α-(ethoxycarbonyloxy)androsta-1,4-diene-17-carboxylic acid chloromethyl ester Synonyms Lotemax Loteprednol Etabonate Lotoprednol etabonate LOTEPREDNOL ETABONATE CDDD-5604, HGP-1, P-5604, Alrex, Lotemax 3-Oxo-11β-hydroxy-17α-(ethoxycarbonyloxy)androsta-1,4-diene-17-carboxylic acid chloromethyl ester 17α-(Ethoxycarbonyloxy)-11β-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid chloromethyl ester 17α-(Ethoxycarbonyloxy)-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid chloromethyl ester chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11b,17a)- Chloromethyl (8xi,9xi,11beta,14xi,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (8xi,9xi,11beta,14xi,17alpha)-
CAS	82034-46-6
EINECS	200-010-0
Chemical Formula	C24H31ClO7
Molecular Weight	466.95
inchi	InChI=1/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Loteprednol Etabonate Loteprednol Etabonate MedChemExpress (MCE) HY-17358 82034-46-6 99.53% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Loteprednol Etabonate Loteprednol Etabonate MedChemExpress (MCE) HY-17358 82034-46-6 99.53% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology. Intravenous administration of Loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect. \| \| \| \| \| \| \| \| \| \| [1]. Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct 10(4):329-39. [Content Brief] [2]. Szelenyi I, Hochhaus G, Heer S et al. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May 36(5):313-20. [Content Brief] [3]. Howes JF. Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie. 2000 Mar 55(3):178-83. [Content Brief] [4]. Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr 92(4):455-9. [Content Brief] [5]. Comstock TL, Decory HH. Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. Int J Inflam. 2012 2012:789623. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Loteprednol-Etabonate.html
Last Update	2025-05-21 16:50:25

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