HOE 36-801 MedChemExpress (MCE)

Product Name	Etifoxine
Synonyms	36-801;Etifoxin;HOE-36801;Etifoxine;HOE-36-801;etafenoxine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
CAS	21715-46-8
EINECS	630-330-6
Chemical Formula	C17H17ClN2O
Molecular Weight	300.78
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Etifoxine Etifoxine MedChemExpress (MCE) HY-16579A 21715-46-8 HOE 36-801 99.96% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Etifoxine Etifoxine MedChemExpress (MCE) HY-16579A 21715-46-8 HOE 36-801 99.96% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents. Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX[1]. Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain[1]. Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice[3]. \| \| \| \| \| \| \| \| \| \| [1]. Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA(A) receptors in rodents. Neurosci Res. 2002 Oct 44(2):167-72. [Content Brief] [2]. Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep 45(3):293-303. [Content Brief] [3]. Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun 21(6):457-70. [Content Brief]
Last Update	2025-04-01 14:45:47

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