CV-4093 MedChemExpress (MCE)

Product Name	MANIDIPINE DIHYDROCHLORIDE
Synonyms	Calslot cv-4093dihydrochlorde franidipinehydrochloride MANIDIPINE HYDROCHLORIDE Manidipine hydrochloride MANIDIPINE DIHYDROCHLORIDE 4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride Synonyms Calslot cv-4093dihydrochlorde franidipinehydrochloride MANIDIPINE HYDROCHLORIDE Manidipine hydrochloride MANIDIPINE DIHYDROCHLORIDE 4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride 2-(4-Benzhydrylpiperazin-1-yl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride 2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride 2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
CAS	89226-75-5
EINECS	680-304-3
Chemical Formula	C35H40Cl2N4O6
Molecular Weight	683.62
inchi	InChI=1/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27 /h4-16,23,32-33,36H,17-22H2,1-3H3 inchi InChI=1/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27 /h4-16,23,32-33,36H,17-22H2,1-3H3 1H
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Manidipine dihydrochloride Manidipine dihydrochloride MedChemExpress (MCE) HY-17403 89226-75-5 CV-4093 99.91% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Manidipine dihydrochloride Manidipine dihydrochloride MedChemExpress (MCE) HY-17403 89226-75-5 CV-4093 99.91% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection. Manidipine dihydrochloride (1 μM, 42 h) suppresses IL-6 secretion in lipoproteins-induced HUVEC[3]. Manidipine dihydrochloride (1 μM, 16 h) suppresses IL-6 secretion in 10 ng/mL IL-1, 10 ng/mL IFN-γ, and 25 ng/mL TNFα treated THP-I [3]. Manidipine dihydrochloride (20 mg/mL, 48/20 h) inhibits propagation/genome replication of SFTSV (a negative-strand RNA virus) in SW13 cells[4]. Manidipine dihydrochloride (20 mg/mL, 48 h) interferes SFTSV N-induced inclusion body formation in Huh-7 cells[4]. Manidipine dihydrochloride (10 mg/kg, i.p., b.i.d. at day 4, day 5) prolongs survival in SFTSV-infected mice[4]. Manidipine dihydrochloride (25 mg/kg, i.p., b.i.d. for 2 d, then daily for 19 d) protects mice from JEV infection[5]. Manidipine dihydrochloride (3 mg/kg, i.g., once per day, 7 d) prevents isoproterenol-induced left ventricular hypertrophy in rats[7]. T-type calcium channel \| \| \| \| \| \| \| \| \| \| [1]. Roca-Cusachs A, et al. Antihypertensive effect of manidipine. Drugs. Drugs. 2005，65，11-19. [Content Brief] [2]. Cavalieri L,, et al. Metabolic effects of manidipine. Am J Cardiovasc Drugs. 2009，9，3. [Content Brief] [3]. Franco Bernini, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010，62，3. [Content Brief] [4]. Urata S, et al. Calcium Influx Regulates the Replication of Several Negative-Strand RNA Viruses Including Severe Fever with Thrombocytopenia Syndrome Virus. J Virol. 2023，97，3. [Content Brief] [5]. Wang S, et al. Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection. J Virol. 2017，91，21. [Content Brief] [6]. Tohse N, et al. Voltage-dependent modulation of L-type Ca2+ current by manidipine in guinea-pig heart cells. Eur J Pharmacol. 1993，249(2):231-3. [Content Brief] [7]. Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Pharmacol Res. 2010Jpn Circ J. 1998，62(1):47-52. [Content Brief]
Last Update	2025-04-01 14:45:47

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