DU-176b monohydrate MedChemExpress (MCE)

Product Name	Edoxaban (tosylate Monohydrate)
Synonyms	Edoxaban tosilate edoxaban tosylate hydrate Edoxaban Tosylate Hydrate 1 Edoxaban (tosylate Monohydrate) Edoxaban p-toluenesulfonate monohydrate N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate hydrate Synonyms Edoxaban tosilate edoxaban tosylate hydrate Edoxaban Tosylate Hydrate 1 Edoxaban (tosylate Monohydrate) Edoxaban p-toluenesulfonate monohydrate N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate hydrate N-(5-Chloropyridin-2-yl)-N'-((1S,2R,4S)-4-[(dimethyl amino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl)ethanediamide p-toluenesulfonate monohydrate Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate
CAS	1229194-11-9
EINECS	1592732-453-0
Chemical Formula	C31H38ClN7O7S2
Molecular Weight	720.26
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Edoxaban tosylate monohydrate Edoxaban tosylate monohydrate MedChemExpress (MCE) HY-10264B 1229194-11-9 DU-176b monohydrate 99.91% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Edoxaban tosylate monohydrate Edoxaban tosylate monohydrate MedChemExpress (MCE) HY-10264B 1229194-11-9 DU-176b monohydrate 99.91% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research. Edoxaban monohydrate (1, 1 and 5 minutes respectively) prolongs PT, TT and APTT of human plasma in a concentration-dependent manner[1].?Edoxaban monohydrate inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM[1]. Edoxaban monohydrate (0.5, 2.5 and 12.5 mg/kg p.o. once) significantly and dose-dependently reduces the thrombus formation and prolongs PT[1]. IC50: 2.90 µM (platelet aggregation), Ki: 0.561 nM (free human FXa), 2.98 nM (prothrombinase), 0.715 nM (cynomolgus monkey FXa), 0.457 nM (rabbit FXa)[1] In Vitro Edoxaban monohydrate (1, 1 and 5 minutes respectively) prolongs PT, TT and APTT of human plasma in a concentration-dependent manner[1].?Edoxaban monohydrate inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Edoxaban tosylate monohydrate Related Antibodies Cell Viability Assay[1] Cell Line: Human, rat, cynomolgus monkey and rabbit plasma Human platelet \| \| \| \| \| \| \| \| \| \| [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep 6(9):1542-9. [Content Brief]
Last Update	2025-04-01 14:45:47

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