CB 676475 MedChemExpress (MCE)

Product Name	ZM 306416
Synonyms	CB676475 CB-676475 CB 676475 ZM 306416 ZM 306416 HYDROCHLORIDE 4-QuinazolinaMine,N-(4-chloro-2-fluorophenyl)-6,7-diMethoxy- 4-[(4'-CHLORO-2'-FLUORO)PHENYLAMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE Synonyms CB676475 CB-676475 CB 676475 ZM 306416 ZM 306416 HYDROCHLORIDE 4-QuinazolinaMine,N-(4-chloro-2-fluorophenyl)-6,7-diMethoxy- 4-[(4'-CHLORO-2'-FLUORO)PHENYLAMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE ZM 213689 DisodiuM Salt (MeropeneM iMpurity) (Mixture of double bond isoMers)
CAS	690206-97-4
EINECS
Chemical Formula	C16H13ClFN3O2
Molecular Weight	333.74
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	ZM 306416 ZM 306416 MedChemExpress (MCE) HY-13785 690206-97-4 CB 676475 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions ZM 306416 ZM 306416 MedChemExpress (MCE) HY-13785 690206-97-4 CB 676475 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM. ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase[2]. KDR 100 nM (IC50) Flt-1 2 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1 16(1):129-33. [Content Brief] [2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug 17(7):885-99. [Content Brief]
Supplier Website	https://www.medchemexpress.com/zm-306416.html
Last Update	2025-05-21 16:50:25

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