INC280; INCB28060 MedChemExpress (MCE)

Product Name	Capmatinib
Synonyms	NVP-INC280 INCB028060 Capmatinib NC280 BenzaMide,2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Capmatinib (INCB28060)
CAS	1029712-80-8
EINECS	813-241-9
Chemical Formula	C23H17FN6O
Molecular Weight	412.42
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Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Capmatinib Capmatinib MedChemExpress (MCE) HY-13404 1029712-80-8 INC280 Descriptions Capmatinib Capmatinib MedChemExpress (MCE) HY-13404 1029712-80-8 INC280 INCB28060 99.92% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Capmatinib (INC280 INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase. Capmatinib (INCB28060) inhibits c-MET phosphorylation with an IC50 value of approximately 1 nM and a concentration of approximately 4 nM inhibits c-MET more than 90%, which is reversible and the effect is significantly reduced in several hours after the compound is removed and completely disappeared by 48 hours[1]. Capmatinib (INCB28060) (0-10000 nM 72 h) inhibits the proliferation of SNU-5, S114, H441 and U-87MG[1]. Capmatinib (INCB28060) (0.06-62.25 nM 2h) effectively inhibits phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5[1]. Capmatinib (INCB28060) (0.24-63 nM over night) prevents HGF-stimulated H441 cell migration[1]. Capmatinib (INCB28060) (0.5-50 nM 20 min) suppresses phosphorylation of both EGFR and HER-3 rapidly[1]. Capmatinib (INCB28060) (0-333 nM 24 h) induces apoptosis in SNU-5 cells[1]. Capmatinib (INCB28060) (1-30 mg/kg PO, twice daily, for 2 weeks) exhibits dose-dependent inhibition of tumor growth, and shows well tolerance at all doses during the treatment periods, with no evidence of overt toxicity or weight loss in U-87MG tumor mice model[1]. Capmatinib (INCB28060) (0.03-10 mg/kg PO, single dosage) causes inhibition of c-MET phosphorylation in S114 tumor mice model[1]. IC50: 0.13 nM (c-MET)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Liu X, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res. 2011 Nov 15 17(22):7127-38. [Content Brief] [2]. Baltschukat S, et al. Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation. Clin Cancer Res. 2019 May 15 25(10):3164-3175. [Content Brief] [3]. Dhillon S. Capmatinib: First Approval. Drugs. 2020 Jul 80(11):1125-1131. [Content Brief]
Last Update	2025-04-01 14:45:47

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