PR-957 MedChemExpress (MCE)

Product Name	(S)-3-(4-methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide
Synonyms	PR957 PR 957 PR-957 PR957 PR-957 PR 957 ONX0914 Synonyms PR957 PR 957 PR-957 PR957 PR-957 PR 957 ONX0914 ONX-0914 ONX 0914 ONX0914 ONX-0914 PR 957(ONX 0914) ONX-0914 (PR-957) N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide (S)-3-(4-methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide
CAS	960374-59-8
EINECS
Chemical Formula	C31H40N4O7
Molecular Weight	580.67
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	ONX-0914 ONX-0914 MedChemExpress (MCE) HY-13207 960374-59-8 PR-957 99.72% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions ONX-0914 ONX-0914 MedChemExpress (MCE) HY-13207 960374-59-8 PR-957 99.72% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1. ONX-0914 inhibits LMP7-specific antigen presentation. ONX-0914 blocks cytokine productionby mouse splenocytes and blocks T celldifferentiation[1]. ONX-0914 (2-10 mg/kg i.v, on days 4, 6 and 8) meliorates disease in mouse arthritis[1]. ?ONX-0914 (2, 6 and 10 mg per kg body weight on days 25, 27, 29, 31 and 33 i.v.) treatment also induced a rapid therapeutic response in the T and B cell–dependent CIA (collagen-induced arthritis) model[1]. HIV-1 \| \| \| \| \| \| \| \| \| \| [1]. Muchamuel T, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis [published correction appears in Nat Med. 2009 Nov 15(11):1333]. Nat Med. 2009 15(7):781-787. [Content Brief] [2]. Rožman K, et al. Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome. Molecules. 2020 25(6):1305. Published 2020 Mar 12. [Content Brief] [3]. Lin J, et al. PR-957, a selective immunoproteasome inhibitor, reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1. Biochem Pharmacol. 2018 156:511-523. [Content Brief]
Last Update	2025-04-01 14:45:47

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